Evidence map›Paper›PMID 39693248›Full record

ArticleThe Journal of infectious diseases2025

Candida albicans Recovered From Persistent Candidemia Exhibits Enhanced Virulence Traits.

Felipe de Camargo Ribeiro, Karoline Kristina Kemmerich, Juliana Caparroz Gonçale, Juliana Campos Junqueira, Mohammad Mannan, Sunna Nabeela, Arnaldo Lopes Colombo, Priya Uppuluri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Felipe de Camargo RibeiroDepartment of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID 0000-0003-3677-3243
Karoline Kristina KemmerichDepartment of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Juliana Caparroz GonçaleDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.ORCID 0000-0002-0670-432X
Juliana Campos JunqueiraDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.
Mohammad MannanDivision of Infection and Immunity, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.
Sunna NabeelaDivision of Infection and Immunity, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.ORCID 0000-0002-8066-2199
Arnaldo Lopes ColomboDepartment of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Priya UppuluriDivision of Infection and Immunity, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA.ORCID 0000-0002-5889-054X

Funding

Targeting the regulatory mechanism of hyphae to lateral yeast growth as a novel therapeutic approach against candidiasisR01AI141794 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI UPPULURI, PRIYA · 2019 to 2022
$1.5M
NIAID NIH HHS R01 AI141794NIH HHS R01AI141794-01A1Sao Paulo Research Foundation 2017/02203-7
6 · The paper itself

Abstract

Candida albicans catheter-related candidemia is largely driven by microbial adhesion and biofilm formation on central venous catheters. Cells that disperse from these biofilms can enter the bloodstream, spread to distant organs, and sustain the cycle of infection. In this study, we investigated the virulence potential of C. albicans isolates obtained from the blood of catheterized patients experiencing persistent candidemia, comparing them to isolates that were cleared from the bloodstream early in the infection. Our results show that isolates persisting in the bloodstream for 4 days or longer, despite antifungal treatment, exhibited enhanced adherence, filamentation, and biofilm formation in vitro, along with increased expression of key virulence-related genes. Notably, cells dispersed from second-generation biofilms formed by these persistent isolates displayed even more pronounced pathogenic characteristics, including improved immune evasion. Furthermore, in vivo experiments using Galleria mellonella revealed that persistent isolates were significantly more virulent than their nonpersistent counterparts.

Indexed as

Candida albicansCandidemiaCatheter-Related InfectionsAnimalsAntifungal AgentsBiofilmsHumansMothsVirulenceVirulence FactorsAntifungal AgentsVirulence Factorsbiofilm dispersalCandida albicansimmune evasionpersistent candidemiavirulence

Identifiers

PMID39693248
PMCPMC11998578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.