ArticleThe Journal of clinical endocrinology and metabolism2025
GLP-1R Gene Polymorphisms and Metabolic Traits During Childhood and Adolescence: The EPOCH Study.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of exercise interventions on bone mineral density in middle-aged and older men: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- RISING STARS: Effects of a GLP-1 receptor polymorphism on responses to liraglutide.The Journal of endocrinology · 2025Trial
- Resistant and Refractory Obesity: The Complexity of Anti-Obesity Therapy Failure.International journal of molecular sciences · 2026Review
- GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes Mellitus and Offspring BMI Growth: The EPOCH Study.Diabetes care · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
contextThis is the first study to examine the association between variants of the glucagon-like-peptide-1 receptor gene (GLP-1R) and metabolic characteristics among youth.
objectiveWe explored separate associations of 3 GLP-1R polymorphisms (rs10305420, rs6923761, and rs1042044) with body mass index (BMI) trajectories and markers of glucose-insulin homeostasis.
methodsMixed models examined associations between GLP-1R polymorphisms and trajectories of BMI. Linear models examined associations of GLP-1R polymorphisms with glucose and insulin concentrations across oral glucose tolerance test (OGTT), insulin sensitivity (HOMA2-IR), insulin secretion (insulinogenic index and HOMA2-%B), and β-cell function (oral disposition index).
resultsRs10305420 and rs6923761, but not rs1042044, were associated with growth and metabolic characteristics in early life. Rs6923761 genotype GG was associated with faster BMI growth velocity, when compared to carriers of the minor allele (difference in velocity [95% CI]: 0.16/year [0.07-0.24] at age 10), which led to significantly higher average BMI by age 16 (average difference [95% CI]: 1.29 [0.22-2.37]). Rs10305420 CC and rs6923761 GG genotypes had higher HOMA2-IR (β [95% CI]: 1.19% [1.06-1.32] and 1.13% [1.01-1.26], respectively) compared to minor allele carriers. Rs10305420 CC had higher HOMA2-%B (β [95% CI]: 1.09% [1.01-1.17]), and higher stimulated insulin secretion at 30 minutes (β [95% CI]: 27.62 μIU/mL [3.00-25.24]) and 120 minutes (β [95% CI]: 18.94 μIU/mL [1.04-36.84]), when compared to carriers of the minor allele.
conclusionGLP-1R polymorphisms are associated with faster BMI growth across development, and lower estimated insulin sensitivity and higher compensatory insulin secretion during adolescence. GLP-1R polymorphisms should be considered in future pediatric studies of genetic susceptibility for obesity and diabetes.
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