Evidence map›Paper›PMID 39693225›Full record

ArticleCell reports2025

Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis.

Mohd Saqib, Shreya Das, Tanvir N Nafiz, Elizabeth McDonough, Poornima Sankar, Lokesh K Mishra, Ximeng Zhang, Yi Cai, Selvakumar Subbian, Bibhuti B Mishra

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  7. Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  8. Article
  9. Review
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  11. Article
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  14. Article
  15. Article
  16. Review
  17. De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Host Immune Response toJournal of inflammation research · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohd SaqibDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Shreya DasDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Tanvir N NafizDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Elizabeth McDonoughGE Healthcare Technology and Innovation Center, GE Research, Niskayuna, NY, USA.
Poornima SankarDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Lokesh K MishraDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Ximeng ZhangGuangdong Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, China.
Yi CaiGuangdong Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University Medical School, Shenzhen, China.
Selvakumar SubbianPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Bibhuti B MishraDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA. Electronic address: mishrab@amc.edu.

Funding

Type II alveolar epithelial cell-intrinsic IL-1 response in protective immunity against tuberculosisR01HL166257 · NHLBI · ALBANY MEDICAL COLLEGE · PI Bibhuti Bhusan Mishra · 2023 to 2026
$2.1M
Decoding the mechanism of protective and pathological functions of IL-1 during TuberculosisR56AI148239 · NIAID · ALBANY MEDICAL COLLEGE · PI MISHRA, BIBHUTI BHUSAN · 2020 to 2020
$487k
NHLBI NIH HHS R01 HL166257NIAID NIH HHS R56 AI148239
6 · The paper itself

Abstract

Neutrophils are vital for immunity against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), yet their heterogeneous nature suggests a complex role in TB pathogenesis. Here, we identify two distinct neutrophil populations based on CD101 expression, highlighting their divergent roles in TB. CD101-negative (CD101

Indexed as

Antigens, CDInterferon Type IMycobacterium tuberculosisNeutrophilsTuberculosisAnimalsGranulocyte Colony-Stimulating FactorHumansLungMiceMice, Inbred C57BLPhagocytosisReceptors, Interleukin-8BAntigens, CDGranulocyte Colony-Stimulating FactorInterferon Type IReceptors, Interleukin-8Bchemokine receptorsCP: ImmunologyCP: Microbiologyextracellular Mycobacterium tuberculosisG-CSFhost-directed therapylow-density neutrophilslung epithelial cellsneutrophil mobilizationneutrophil subsetstissue damagetype I interferon

Identifiers

PMID39693225
PMCPMC11829800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.