Evidence map›Paper›PMID 39692924›Full record

ArticleDiscover oncology2024

Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression.

Zhili Zhuo, Wenping Lu, Ling Zhang, Dongni Zhang, Yongjia Cui, Xiaoqing Wu, Heting Mei, Lei Chang, Qingya Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhili ZhuoOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.
Wenping LuOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China. lu_wenping@sina.com.
Ling ZhangDepartment of pathology, China Academy of Chinese Medical Sciences Guang' anmen Hospital, Beijing, 100053, China.
Dongni ZhangOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.
Yongjia CuiOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.
Xiaoqing WuOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.
Heting MeiOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.
Lei ChangOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.
Qingya SongOncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.

Funding

High Level Chinese Medical Hospital Promotion Project - Special Project on Formulation R&D and New Drug Translation for Medical Institutions HLCMHPP2023037State Administration of Traditional Chinese Medicine (SACM) ZYZB-2022-798
6 · The paper itself

Abstract

TNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents a promising approach for addressing TNBC. Anxiety and depression are frequently concurrent symptoms in TNBC patients. MDD affects the tumor immune microenvironment of TNBC, with its characteristic genes affecting the pathophysiology of MDD and potentially increasing the risk of TNBC recurrence and metastasis. This study reveals significant differences in T lymphocyte infiltration between high-risk and low-risk TNBC groups based on MDD feature genes. This finding aids in identifying TNBC patients who may benefit from immunotherapy, providing new insights for future TNBC immunotherapy strategies. Our aim is to identify MDD-related genes involved in the pathogenesis of TNBC and to provide predictive biomarkers for TNBC immunotherapy.

Indexed as

Immune cell infiltrationMajor depressive disorderPrognostic valueSingle-cell sequencingTriple-negative breast cancer

Identifiers

PMID39692924
PMCPMC11655728

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.