ArticleDiscover oncology2024
Lipid metabolism subtypes reflects the prognosis and immune profiles of bladder cancer patients by NMF clustering and building related signature.
Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipid metabolism is crucial in tumor formation and progression. However, the role of lipid metabolism genes (LMGs) in bladder cancer (BLCA) are unknown. The purpose of this study was to construct a LMGs-related subtypes that predicted the treatment and prognosis of BLCA patients.
methodsThe Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used for this study. The gene set enrichment analysis (GSEA) was utilized to distinguish functional differences between high-risk (HR) and low-risk (LR) groups. Single-sample GSEA (ssGSEA) was employed to determine potential associations between prognostic outcomes and immune status.
resultsFirst, BLCA patients were divided into two subtypes by non-negative matrix factorization (NMF) clustering, and there were substantial variations in survival status, immune cell infiltration and immune classification between the two subtypes. Next, a prognostic signature involving 8 LMGs was identified (AKR1B1, SCD, CYP27B1, UGCG, SGPL1, FASN, TNFAIP8L3, PLA2G2A). HR patients exhibited worse outcome than LR patients. Multivariate Cox regression analysis confirmed that LMGs-related signature was an independent prognostic indicator of BLCA patients' survival. Compared with clinicopathological variables, LMGs-related signature showed higher prognostic predictive ability, with an area under curve of 0.720 at 5 years of follow-up. Through immunotherapy analysis, drug sensitivity analysis, TIDE score and immune cell infiltration characteristics, LMGs-related signature was confirmed to accurately predict the prognosis and treatment response of BLCA patients.
conclusionOur newly established prognostic signature, which involved eight LMGs, can give prognostic distinction for BLCA and may eventually lead to novel targets for treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.