ArticleMolecular biology reports2024
Phosphoproteomic analysis uncovers phosphorylated proteins in response to salicylic acid and N-hydroxypipecolic acid in Arabidopsis.
Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- PGPR-Mediated Plant Immunity: From Microbial Recognition to Epigenetic Priming.Plants (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe phytohormone salicylic acid (SA) serves as a crucial signaling molecule within the realm of plant immunity, playing an indispensable role in both local and systemic acquired resistance (SAR). N-hydroxypipecolic acid (NHP), a derivative of L-lysine, is integral to the induction of SAR. Recent investigations have illuminated the intricate manner in which NHP orchestrates the establishment of SAR in conjunction with the immune signal SA. METHODS AND
resultsTo further explore the mechanisms governing the synergistic regulation of SAR by SA and NHP, we conducted an extensive phosphoproteomic analysis aimed at identifying the phosphoproteins modulated either commonly or uniquely by SA and NHP, employing a phosphoproteomics platform built upon high-resolution mass spectrometry. Our study revealed a total of 133 phosphopeptides, derived from 115 distinct proteins, exhibiting exclusive responsiveness to NHP treatment. In contrast, 229 phosphopeptides sourced from 204 proteins demonstrated exclusive sensitivity to SA treatment. Additionally, the phosphorylation status of 215 proteins, including numerous kinases, phosphatases, transcription factors, and proteins implicated in membrane trafficking, was commonly modulated by both SA and NHP.
conclusionThis investigation offers detailed insights into the key phosphoproteins influenced either collectively or specifically by SA and NHP, thereby enabling further exploration of the mechanisms underlying the synergistic regulation of immune responses orchestrated by these two potent molecules.
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Registered trials
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