Evidence map›Paper›PMID 39692851›Full record

ReviewEJNMMI radiopharmacy and chemistry2024

Novel radionuclides: demand, production and distribution for translational research in Europe.

Maija Radzina, Laura Saule, Edgars Mamis, Elina Pajuste, Ulli Koester, Thomas Elias Cocolios, Jevgenijs Proskurins, Patricija Kalnina, Rudolfs Janis Zabolockis, Kristaps Palskis and 6 more

Abstract readReview
In one paragraph

Review in EJNMMI radiopharmacy and chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maija RadzinaUniversity of Latvia, Riga, Latvia.ORCID http://orcid.org/0000-0002-9518-4855
Laura SauleUniversity of Latvia, Riga, Latvia. laura.dronka@gmail.com.ORCID http://orcid.org/0000-0003-0477-9886
Edgars MamisUniversity of Latvia, Riga, Latvia.ORCID https://orcid.org/0000-0003-4276-5469
Elina PajusteUniversity of Latvia, Riga, Latvia.ORCID https://orcid.org/0000-0003-1036-4679
Ulli KoesterInstitut Laue-Langevin, Grenoble, France.ORCID https://orcid.org/0000-0001-5701-3249
Thomas Elias CocoliosKU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-0456-7878
Jevgenijs ProskurinsRiga Stradins University, Riga, Latvia.ORCID https://orcid.org/0000-0003-4458-7328
Patricija KalninaUniversity of Latvia, Riga, Latvia.ORCID https://orcid.org/0009-0001-4506-4388
Rudolfs Janis ZabolockisUniversity of Latvia, Riga, Latvia.ORCID https://orcid.org/0000-0002-6654-9982
Kristaps PalskisCERN, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-7184-3951
Zeynep TalipPaul Scherrer Institute, Villigen-PSI, Switzerland.ORCID https://orcid.org/0000-0002-5095-799X
Mikael JensenTechnical University of Denmark, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0002-9109-2187
Charlotte DucheminCERN, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-3661-7833
Sarah BaatoutBelgian Nuclear Research Centre (SCK CEN), Mol, Belgium.ORCID https://orcid.org/0000-0001-8110-751X
Kirsten LeufgenSCIPROM Sarl, Saint-Sulpice, Switzerland.
Thierry StoraCERN, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-4308-1002

Funding

European Union's Horizon 2020 research and innovation programme 101008571 (PRISMAP)
6 · The paper itself

Abstract

backgroundIn the field of medical and scientific research, radionuclides are used to investigate various physiological and pathological processes. PRISMAP - the European medical radionuclide programme was created to bring together production facilities including intense neutron sources, an isotope mass separation facility, high-power accelerators, biomedical research institutes, and hospitals to support medical research. The aim of this article is to introduce readers with the current status of innovative radionuclides in Europe. MAIN BODY: A survey was created targeting the latest trends mainly focused on the demand, the production and the distribution of non-routinely used medical radionuclides for use in research, and for pre-clinical and clinical trials. This survey has been disseminated through the PRISMAP community. 16 of 104 respondents were working in the field of radionuclide production. The data found common aspects from all producer-facility respondents: the biggest challenge for the producers is the availability of target materials, which goes hand-in-hand with their purity/enrichment grade. The results show that there are sufficient national or international distribution routes and methods established, although having reported challenges due to legislation constraints, especially for novel radionuclides.

conclusionsThanks to a questionnaire distributed by the PRISMAP consortium, the current status in radionuclides production was identified. Understanding the current status of radionuclide production is essential for assessing the continent's capabilities and addressing the burgeoning demands for cutting-edge medical radionuclides.

Indexed as

DiagnosticPET/CTPRISMAPRadionuclidesTherapy

Identifiers

PMID39692851
PMCPMC11655791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.