Trial reportJournal of cosmetic dermatology2025
Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- An Innovative Serum With Retinol, Hydroxypinacolone Retinoate, Peptides, and Silybin Improves Mild Photoaged Facial Skin in Middle-Aged Chinese Women.Journal of cosmetic dermatology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin A, or retinol, is one of the most effective antiaging molecules, but it presents issues with photo-sensitivity and irritation. Alternatives are emerging, but have so far been less effective.
objectiveHere, we present a Silibum marianum extract (SME) as a retinol-like ingredient providing both safety and efficacy. SME was compared to the reference compound, retinol, and to the main alternative, bakuchiol.
methodsSkin explants from a 58-year-old donor were treated with pure retinol (0.1%), bakuchiol (0.2%), or SME (0.8%). After 5 days, collagen and hyaluronic acid levels were analyzed. A placebo-controlled study involving 57 volunteers was also conducted, with products applied twice daily for 56 days. Results were measured by AEVA-HE and VISA.
resultsLevels of collagen III were significantly increased by SME, by 23% and 16% compared to bakuchiol and retinol respectively. Compared to bakuchiol, SME treatment increased hyaluronic acid production by 36%. In clinical tests, SME had a significantly stronger anti-wrinkle effect than bakuchiol-reducing the number of wrinkles on the forehead by 21% and their circumference by 17%-producing effects similar to retinol, and better than bakuchiol. In the self-assessment, 43% of volunteers reported discomfort while using retinol compared to 0% for the SME formulation. By enhancing levels of collagen III-the youth collagen-and hyaluronic acid in the skin, SME paves the way for the maturation of collagen I fibrils and skin plumping.
conclusionWith its stronger efficacy compared to bakuchiol and enhanced safety profile compared to retinol, SME may be the next generation of natural alternatives to retinoids.
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