Evidence map›Paper›PMID 39692709›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

The Na

Dennis Bo Jensen, Trine L Toft-Bertelsen, Dagne Barbuskaite, Jane Stubbe, Sandor Nietzsche, Tenna Capion, Nicolas H Norager, Markus H Olsen, Andreas T Sørensen, Henrik Dimke and 3 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. The NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dennis Bo JensenDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen N, 2200, Denmark.
Trine L Toft-BertelsenDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen N, 2200, Denmark.
Dagne BarbuskaiteDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen N, 2200, Denmark.
Jane StubbeDepartment of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark.
Sandor NietzscheCenter for Electron Microscopy, Jena University Hospital, Ziegelmühlenweg 1, 07743, Jena, Germany.
Tenna CapionDepartment of Neurosurgery, University Hospital of Copenhagen - Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Nicolas H NoragerDepartment of Neurosurgery, University Hospital of Copenhagen - Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Markus H OlsenDepartment of Neuroanaesthesiology, University Hospital of Copenhagen - Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Andreas T SørensenDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen N, 2200, Denmark.
Henrik DimkeDepartment of Nephrology, Odense University Hospital, J.B. Winsløws Vej 4, Odense, 5000, Denmark.
Christian A HübnerHübner, Institute of Human Genetics, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
Marianne JuhlerDepartment of Neurosurgery, University Hospital of Copenhagen - Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Nanna MacAulayDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen N, 2200, Denmark.ORCID https://orcid.org/0000-0002-7800-6600

Funding

Danmarks Frie Forskningsfond 0134-00077BDFG to CAH HU 800/16-1Lundbeck Foundation R303-2018-3005Novo Nordisk Fonden NNF17OC0024718
6 · The paper itself

Abstract

Disturbances in the brain fluid balance can lead to life-threatening elevation in intracranial pressure (ICP), which represents a vast clinical challenge. Targeted and efficient pharmaceutical therapy of elevated ICP is not currently available, as the molecular mechanisms governing cerebrospinal fluid (CSF) secretion are largely unresolved. To resolve the quantitative contribution of key choroid plexus transport proteins, this study employs mice with genetic knockout and/or viral choroid plexus-specific knockdown of aquaporin 1 (AQP1) and the Na

Indexed as

Aquaporin 1BrainCerebrospinal FluidHomeostasisPotassiumSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2AnimalsChoroid PlexusHumansIntracranial PressureMaleMiceMice, KnockoutAquaporin 1PotassiumSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2aquaporinchoroid plexusCSFhydrocephalusK+NKCC1

Identifiers

PMID39692709
PMCPMC11809428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.