Evidence map›Paper›PMID 39692624›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.

Courtney M Kloske, Simin Mahinrad, Christopher J Barnum, Andre F Batista, Elizabeth M Bradshaw, Brittany Butts, Maria C Carrillo, Paramita Chakrabarty, Xiaoying Chen, Suzanne Craft and 32 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Courtney M KloskeAlzheimer's Association, Chicago, Illinois, USA.
Simin MahinradAlzheimer's Association, Chicago, Illinois, USA.
Christopher J BarnumINmune Bio, Inc., Boca Raton, Florida, USA.
Andre F BatistaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Elizabeth M BradshawDepartment of Neurology, The Carol and Gene Ludwig Center for Research on Neurodegeneration, Division of Translational Neurobiology, Columbia University, New York, New York, USA.
Brittany ButtsEmory University, Atlanta, Georgia, USA.
Maria C CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Paramita ChakrabartyDepartment of Neuroscience, Center for Translational Research in Neurodegenerative Diseases, University of Florida, Gainesville, Florida, USA.
Xiaoying ChenDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Suzanne CraftAlzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sandro Da MesquitaDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Luke C DabinDepartment of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Davangere DevanandColumbia University Irving Medical Center, New York, New York, USA.
Violeta Duran-LaforetDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Wassim ElyamanDepartment of Neurology, Division of Translational Neurobiology, Columbia University Irving Medical Center, New York, New York, USA.
Elizabeth E EvansVaccinex, Inc, Rochester, New York, USA.
Patricia Fitzgerald-BocarslyRutgers New Jersey Medical School, Newark, New Jersey, USA.
Kate E FoleyDepartment of Neurology, Stark Neurosciences Research Institute, Indiana University, Indianapolis, Indiana, USA.
Ashley S HarmsDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Michael T HenekaLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belval, Luxembourg.
Soyon HongUK Dementia Research Institute at University College London, Institute of Neurology, London, UK.
Yu-Wen A HuangBrown University, Providence, Rhode Island, USA.
Stephanie JackvonyAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Neuroscience Graduate Program, Weill Cornell Medicine, New York, New York, USA.
Laijun LaiUniversity of Connecticut, Storrs, Connecticut, USA.
Yann Le GuenDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Cynthia A LemereDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Shane A LiddelowDepartments of Neuroscience & Physiology and Ophthalmology, Neuroscience Institute, NYU Grossman School of Medicine, New York, New York, USA.
Alfonso Martin-PeñaDepartment of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Anna G OrrAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Neuroscience Graduate Program, Weill Cornell Medicine, New York, New York, USA.
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Grace D RameyBiological and Medical Informatics PhD Program, University of California San Francisco, San Francisco, California, USA.
Jessica E RexachProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Stacey J S RizzoAging Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Claire SextonAlzheimer's Association, Chicago, Illinois, USA.
Alice S TangBakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, California, USA.
Jose G TorrellasCenter for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, USA.
Andy P TsaiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
Lynn van OlstThe Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Keenan A WalkerLaboratory of Behavioral Neuroscience, National Institute on Aging (NIA) Intramural Research Program, Baltimore, Maryland, USA.
Whitney WhartonSchool of Nursing, Emory University, Atlanta, Georgia, USA.
Malú Gámez TanseyDepartment of Neuroscience, University of Florida College of Medicine, McKnight Brain Institute, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Donna M WilcockDepartment of Neurology, Stark Neurosciences Research Institute, Indiana University, Indianapolis, Indiana, USA.

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gareth R Howell · 2016 to 2026
$95.6M
TREAT AD Structural Biology CoreU54AG065187 · NIA · EMORY UNIVERSITY · PI Gregory W Carter, ALLAN I LEVEY · 2019 to 2026
$69.7M
Structural Biology CoreU54AG065181 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Bruce T Lamb, Alan D. Palkowitz · 2019 to 2026
$61.3M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Pamela J McLean · 2019 to 2026
$33.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's diseaseR01AG075802 · NIA · MAYO CLINIC JACKSONVILLE · PI BERNARDINO Francesco GHETTI, Lea Tenenholz Grinberg · 2022 to 2026
$15.5M
Therapeutic Effect of Intranasal Insulin on Cognition, Function, and AD BiomarkerRF1AG041845 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CRAFT, SUZANNE · 2012 to 2017
$13.1M
Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans SUPPLEMENTR01AG053961 · NIA · RUTGERS THE STATE UNIV OF NJ NEWARK · PI MARK A GLUCK · 2018 to 2026
$10.6M
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
An Integrative Multi-Omics Approach to Elucidate Sex-Specific Differences in Alzheimers DiseaseR01AG060393 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIROTA, MARINA · 2018 to 2022
$4.1M
Intersection of HSV-1 and microglial genetics in ADR01AG076018 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRADSHAW, ELIZABETH M, ELYAMAN, WASSIM · 2021 to 2025
$3.8M
Alzheimer Nederland Impulssubsidie WE.06-2023-03Alzheimer's Association AARF-22-23219Alzheimer's Association ZenithBrightFocus Foundation A2021025SBrightFocus Foundation A2022006FCure Alzheimer's FundDepartment of Defense AL200097Department of Defense AL210128Department of Defense AL230130Early Career WE.03-2023-08European Union's Horizon 2020Glaucoma Research FoundationInfectious Diseases Society of AmericaJohn Douglas French Alzheimer's FoundationMarie Sklodowska-Curie 890650Medical Scientist Training Program T32GM007618NIAMS NIH HHS 1F30AG079504-01NIAMS NIH HHS NIH P30 AR070155NIAMS NIH HHS P30 AR070155NIAMS NIH HHS R01AG060393NIAMS NIH HHS T32GM007618NIA NIH HHS 1F30AG079504-01NIA NIH HHS 1F31AG079616-01NIA NIH HHS 3R01AG067581-04S1NIA NIH HHS 5R01AG067581NIA NIH HHS F30 AG079504NIA NIH HHS F31 AG079616NIA NIH HHS K23 AG076977NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG053961NIA NIH HHS R01 AG060393NIA NIH HHS R01AG060393NIA NIH HHS R01 AG066203NIA NIH HHS R01 AG067581NIA NIH HHS R01 AG075802NIA NIH HHS R01 AG076018NIA NIH HHS R01 AG083943NIA NIH HHS R21 AG067368NIA NIH HHS R21 AG072234NIA NIH HHS R21AG072234NIA NIH HHS R21 AG073882NIA NIH HHS R24 AG066599NIA NIH HHS R56 AG083943NIA NIH HHS RF1 AG041845NIA NIH HHS RF1 AG080556NIA NIH HHS U19AG07486NIA NIH HHS U54 AG054345NIA NIH HHS U54AG054345NIA NIH HHS U54 AG065181NIA NIH HHS U54AG065181NIA NIH HHS U54 AG065187NIA NIH HHS U54AG065187NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM136566NIH HHS 1R01AG066203-02NIH HHS 5R01AG053961NIH HHS AG083943NIH HHS K08 NS105916NIH HHS K23AG076977NIH HHS P30 AG072947NIH HHS R01AG067581NIH HHS R01 AG075802NIH HHS R01AG076018NIH HHS R01 AG10882NIH HHS R21AG067368-02S1NIH HHS R21AG073882NIH HHS R24AG066599NIH HHS RF1 AG041845NIH HHS RF1NS128800NIH/NIA 1RF1AG080556-01A1NINDS/NIA 1R01NS118569NINDS NIH HHS K08 NS105916NINDS NIH HHS R01 NS118569NINDS NIH HHS RF1 NS128626NINDS NIH HHS RF1NS128626NINDS NIH HHS RF1 NS128800Parkinson's Foundation PF-IMP-870699Rainwater Charitable FoundationUK Dementia Research Institute UKDRI-1011
6 · The paper itself

Abstract

The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated. In March of 2023, the Alzheimer's Association convened the Alzheimer's Association International Conference (AAIC), Advancements: Immunity, to discuss the roles of the immune system in ADRD. A wide range of topics were discussed, such as animal models that replicate human pathology, immune-related biomarkers and clinical trials, and lessons from other fields describing immune responses in neurodegeneration. This manuscript presents highlights from the conference and outlines avenues for future research on the roles of immunity in neurodegenerative disorders. HIGHLIGHTS: The immune system plays a central role in the pathogenesis of Alzheimer's disease. The immune system exerts numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The 2023 AAIC, Advancements: Immunity, encouraged discussions and collaborations on understanding the role of the immune system.

Indexed as

Alzheimer DiseaseBrainDementiaAnimalsCongresses as TopicHumansAlzheimer's diseaseimmunityinflammationmicrogliatherapeutics

Identifiers

PMID39692624
PMCPMC11772715

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.