Evidence map›Paper›PMID 39692595›Full record

ArticleACS applied materials & interfaces2025

Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy.

Natália Noronha Ferreira, Celisnolia Morais Leite, Natália Sanchez Moreno, Renata Rank Miranda, Paula Maria Pincela Lins, Camila Fernanda Rodero, Edilson de Oliveira Junior, Eliana Martins Lima, Rui M Reis, Valtencir Zucolotto

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Multifunctional CuFrontiers in chemistry · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natália Noronha FerreiraNanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, São Paulo University, Avenida Trabalhador São Carlense, 400, São Carlos, SP 13560-970, Brazil.ORCID 0000-0002-5090-9971
Celisnolia Morais LeiteNanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, São Paulo University, Avenida Trabalhador São Carlense, 400, São Carlos, SP 13560-970, Brazil.ORCID 0000-0003-0933-9767
Natália Sanchez MorenoNanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, São Paulo University, Avenida Trabalhador São Carlense, 400, São Carlos, SP 13560-970, Brazil.
Renata Rank MirandaNanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, São Paulo University, Avenida Trabalhador São Carlense, 400, São Carlos, SP 13560-970, Brazil.ORCID 0000-0001-8774-2418
Paula Maria Pincela LinsHasselt University, Faculty of Medicine and Life Sciences, Biomedical Research Institute (BIOMED), Agoralaan, 3590 Diepenbeek, Belgium.ORCID 0000-0002-8663-4463
Camila Fernanda RoderoNanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, São Paulo University, Avenida Trabalhador São Carlense, 400, São Carlos, SP 13560-970, Brazil.
Edilson de Oliveira JuniorLaboratório de Nanotecnologia Farmacêutica e Sistemas de Liberação de Fármacos, FarmaTec, Faculdade de Farmácia, Universidade Federal de Goiás - UFG, 5a Avenida c/Rua 240 s/n, Praça Universitária, Goiânia, GO 74605-170, Brazil.
Eliana Martins LimaLaboratório de Nanotecnologia Farmacêutica e Sistemas de Liberação de Fármacos, FarmaTec, Faculdade de Farmácia, Universidade Federal de Goiás - UFG, 5a Avenida c/Rua 240 s/n, Praça Universitária, Goiânia, GO 74605-170, Brazil.
Rui M ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331, Barretos, SP 14784-400, Brazil.ORCID 0000-0002-9639-7940
Valtencir ZucolottoNanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, São Paulo University, Avenida Trabalhador São Carlense, 400, São Carlos, SP 13560-970, Brazil.ORCID 0000-0003-4307-3077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is an extremely aggressive form of brain cancer that remains challenging to treat, especially owing to the lack of effective targeting and drug delivery concerns. Due to its anatomical advantages, the nose-to-brain strategy is an interesting route for drug delivery. Nanoengineering has provided technological tools and innovative strategies to overcome biotechnological limitations, which is promising for improving the effectiveness of conventional therapies. Herein, we designed a biomimetic multifunctional nanostructure produced by polymeric poly(d,l-lactic-

Indexed as

Biomimetic MaterialsBrain NeoplasmsGlioblastomaNanoparticlesTemozolomideAdministration, IntranasalAnimalsBrainCell Line, TumorDrug CarriersDrug Delivery SystemsHumansPolylactic Acid-Polyglycolic Acid CopolymerSwineTissue DistributionDrug CarriersPolylactic Acid-Polyglycolic Acid CopolymerTemozolomidebiomimetic delivery systemsglioblastoma treatmenthomotypic recognitionnanotechnologynose-to-brain deliveryPLGA-based nanoparticlesTemozolomide

Identifiers

PMID39692595
PMCPMC11783514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.