ArticleMedicine and science in sports and exercise2025
Associations of Habitual Skeletal Loading with Bone Changes during the Menopausal Transition: A Follow-Up Study.
Article in Medicine and science in sports and exercise, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhile weight-bearing physical activity benefits bone health, it remains unclear whether physical activity can counteract hormone-driven menopausal bone deterioration. This secondary analysis of a population-based prospective follow-up study examined changes in bone health indicators around menopause and evaluated whether accelerometer-measured habitual skeletal loading is associated with these changes.
methodsA total of 189 initially perimenopausal women without estrogen therapy (mean age, 52 yr; SD, 2 yr) were followed until they became postmenopausal (mean follow-up time, 15 months; SD, 9 months). Femoral neck bone mineral density (FN BMD) and bone mineral content were measured with dual x-ray absorptiometry. Femoral and tibial shaft volumetric BMD (vBMD), cross-sectional geometry, and stress-strain index (SSI) were assessed using quantitative computed tomography in a subset of 61 women. Habitual skeletal loads (mean daily osteogenic index and low-, medium-, and high-intensity impact counts) were evaluated with multiple-day free-living accelerometry records. Longitudinal associations of habitual skeletal loads and bone outcomes were analyzed with generalized estimating equation models.
resultsConsistent decreases were observed in FN BMD and bone mineral content, and femoral and tibial shaft vBMD and SSI ( P < 0.001) over the follow-up. Slight decreases over the follow-up were also observed in osteogenic index and medium impacts in the full sample, and medium and high impact counts in the subsample ( P < 0.05). Medium impacts were associated with tibial shaft vBMD and SSI (β = 0.204; 95% confidence interval [95% CI], 0.018-0.391 and β = 0.077; 95% CI, 0.000-0.154, respectively). High impacts were associated with femoral shaft vBMD (β = 0.186; 95% CI, 0.006-0.366). However, no association was observed between habitual skeletal loads and changes in bone characteristics over the follow-up.
conclusionsWe observed a rather uniform skeletal response to the menopausal transition at all measured bone sites. Positive associations were found between medium and high-intensity impacts and bone characteristics at the femoral and tibial shafts. However, habitual skeletal loading did not seem to counteract bone deterioration during the menopausal transition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.