Evidence map›Paper›PMID 39692568›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2025

Early Continuous Electroencephalography, Clinical Parameters, and Short-Term Functional Outcomes in Pediatric Traumatic Brain Injury: Single-Center, Retrospective Cohort, 2010-2020.

Akilah Pascall, Anqing Zhang, Omar Dughly, Michael J Bell, Dana Harrar, Terry Dean

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akilah PascallDivision of Critical Care Medicine, Children's National Medical Center, The George Washington University School of Medicine Washington, DC.
Anqing ZhangDivision of Biostatistics and Study Methodology, Children's National Hospital, Washington, DC.
Omar DughlyDivision of Critical Care Medicine, Children's National Medical Center, The George Washington University School of Medicine Washington, DC.
Michael J BellDivision of Critical Care Medicine, Children's National Medical Center, The George Washington University School of Medicine Washington, DC.
Dana HarrarDepartment of Neurology, Children's National Medical Center, George Washington University School of Medicine, Washington, DC.
Terry DeanDivision of Critical Care Medicine, Children's National Medical Center, The George Washington University School of Medicine Washington, DC.

Funding

Endogenous circadian clocks regulate NG2-glia regenerative potentialK08NS131529 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI Terry Dean · 2023 to 2026
$728k
NINDS NIH HHS K08 NS131529
6 · The paper itself

Abstract

objectivesTraumatic brain injury (TBI) is a leading cause of pediatric morbidity and mortality. This study first investigates clinical characteristics and continuous electroencephalography (cEEG) parameters associated with short-term functional outcomes in pediatric patients following TBI. Second, we use these data for a hypothesis-generating model about outcomes.

designRetrospective cohort study.

settingPICU within a quaternary care hospital. PATIENTS: Pediatric patients (< 18 yr) admitted from January 2010 to December 2020 with TBI who underwent cEEG within 72 hours of admission.

interventionsNone. MEASUREMENTS AND MAIN

resultsPatient demographics, clinical parameters, hospital course, and cEEG features were reviewed for associations with mortality and new disability (as defined by change in Functional Status Score between admission and discharge of ≥ 3 points). A statistical prediction model for patient outcome was created combining cEEG parameters with admission Glasgow Coma Scale (GCS) score and radiographic findings. We included 142 patients: 100 (70%) of whom had no new disability at hospital discharge; 42 (30%) had a new disability, including eight deaths. Univariate analysis showed favorable outcomes were associated with normal electroencephalogram background, reactivity, and sleep features ( p < 0.001 for each). A model inclusive of these electroencephalogram parameters and GCS had high predictive ability for outcome with 0.94 with 95% CI (0.90-0.98).

conclusionsSpecific cEEG findings observed acutely after injury, in combination with other clinical characteristics, may serve as biomarkers for short-term functional outcomes after pediatric TBI. Further validation of the model in another population is now required.

Indexed as

Brain Injuries, TraumaticElectroencephalographyAdolescentChildChild, PreschoolFemaleGlasgow Coma ScaleHumansInfantIntensive Care Units, PediatricMaleRetrospective Studies

Identifiers

PMID39692568
PMCPMC13430564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.