Evidence map›Paper›PMID 39692514›Full record

ArticlemBio2025

DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge.

Victoria Gnazzo, Hanaa Saleh, Ítalo A Castro, Adrianus C M Boon, Amelia K Pinto, James D Brien, Carolina B López

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. mRNA Vaccines for Influenza: Hope for a Universal Vaccine?BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Evaluation ofInfection and immunity · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Victoria GnazzoDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0002-3381-5834
Hanaa SalehDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Ítalo A CastroDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Adrianus C M BoonDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0002-4700-8224
Amelia K PintoDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-7147-3978
James D BrienDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.
Carolina B LópezDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0002-7669-6572

Funding

Translational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4M
SARS-CoV-2 correlates of protection in a Latino-origin populationU01CA260541 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BRIEN, JAMES D, LOPEZ, MARCOS · 2020 to 2024
$3.4M
Mechanisms of DDO AdjuvancyR01AI134862 · NIAID · WASHINGTON UNIVERSITY · PI LOPEZ, CAROLINA B. · 2018 to 2022
$2.4M
Harnessing ZBP1-driven cell death to improve influenza vaccine efficacyR56AI150965 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, LANGLOIS, RYAN · 2021 to 2021
$848k
Transcriptional and functional profiling of cross-reactive T cells to understand outcomes for the pathogen and host during heterologous infectionF31AI152460 · NIAID · SAINT LOUIS UNIVERSITY · PI HASSERT, MARIAH A · 2020 to 2021
$46k
Interferon regulation of the blood brain barrier during West Nile encephalitisF31NS087866 · NINDS · WASHINGTON UNIVERSITY · PI DANIELS, BRIAN · 2014 to 2014
$29k
HHS | National Institutes of Health (NIH) 3U01CA260541-02S1HHS | National Institutes of Health (NIH) R01AI134862HHS | National Institutes of Health (NIH) R01AI1506701A1HHS | National Institutes of Health (NIH) R56AI150965NCI NIH HHS U01 CA260541NIAID NIH HHS F31 AI152460NIAID NIH HHS R01 AI134862NIAID NIH HHS R56 AI150965NIH HHS P40 OD012217NINDS NIH HHS F31 NS087866
6 · The paper itself

Abstract

A challenge in viral vaccine development is to produce vaccines that generate both neutralizing antibodies to prevent infection and cytotoxic CD8

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineImmunity, CellularImmunity, HumoralInfluenza A virusInfluenza VaccinesNucleoproteinsOrthomyxoviridae InfectionsRNA-Binding ProteinsViral Core ProteinsAnimalsAntibodies, NeutralizingAntibodies, ViralCD8-Positive T-LymphocytesFemaleMiceAdjuvants, ImmunologicAdjuvants, VaccineAntibodies, NeutralizingAntibodies, ViralInfluenza VaccinesmRNA VaccinesNP protein, Influenza A virusNucleocapsid ProteinsNucleoproteinsRNA-Binding ProteinsRNA, MessengerVaccines, SyntheticViral Core ProteinsadjuvantsmRNA vaccinetype I IFN

Identifiers

PMID39692514
PMCPMC11796404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.