Evidence map›Paper›PMID 39692230›Full record

ArticleArchiv der Pharmazie2025

5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates.

Ester Colarusso, Gianluigi Lauro, Marianna Potenza, Paola Galatello, Maria Luisa d'Aulisio Garigliota, Maria Grazia Ferraro, Marialuisa Piccolo, Maria Giovanna Chini, Carlo Irace, Pietro Campiglia and 4 more

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Potential Nutraceutical Properties ofMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ester ColarussoDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Gianluigi LauroDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Marianna PotenzaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Paola GalatelloDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Maria Luisa d'Aulisio GarigliotaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Maria Grazia FerraroDepartment of Molecular Medicine and Medical Biotechnologies, School of Medicine and Surgery, University of Naples, Naples, Italy.
Marialuisa PiccoloBioChem Lab, Department of Pharmacy, School of Medicine and Surgery, University of Naples, Naples, Italy.
Maria Giovanna ChiniDepartment of Biosciences and Territory, University of Molise, Pesche, Italy.
Carlo IraceBioChem Lab, Department of Pharmacy, School of Medicine and Surgery, University of Naples, Naples, Italy.
Pietro CampigliaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Robert Klaus HoffstetterDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany.
Oliver WerzDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany.
Anna RamunnoDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Giuseppe BifulcoDepartment of Pharmacy, University of Salerno, Fisciano, Italy.ORCID http://orcid.org/0000-0002-1788-5170

Funding

AIRC 28846 projectDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) 316213987Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) SFB1278
6 · The paper itself

Abstract

Inhibiting microsomal prostaglandin E

Indexed as

Antineoplastic AgentsEnzyme InhibitorsEpoxide HydrolasesProstaglandin-E SynthasesPyrrolesCell Line, TumorColorectal NeoplasmsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsEnzyme InhibitorsEpoxide HydrolasesProstaglandin-E SynthasesPTGES protein, humanPyrroles5‐methyl‐2‐carboxamidepyrrole‐based compoundscancerdocking experimentsmPGES‐1sEH

Identifiers

PMID39692230
PMCPMC11653428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.