Evidence map›Paper›PMID 39692068›Full record

Trial reportEuropean journal of heart failure2025

Association between body mass index and clinical outcomes in patients with acute myocardial infarction and reduced systolic function: Analysis of PARADISE-MI trial data.

Offer Amir, Gabby Elbaz-Greener, Shemy Carasso, Brian Claggett, Olga Barbarash, Azfar Zaman, Christina Christersson, Songsak Kiatchoosakun, John Anonuevo, Grzegorz Opolski and 12 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Offer Amir *Department of Cardiology, Hadassah Medical Center, Jerusalem, Israel.
Gabby Elbaz-Greener *Department of Cardiology, Hadassah Medical Center, Jerusalem, Israel.ORCID https://orcid.org/0000-0003-1922-9174
Shemy CarassoFaculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Brian ClaggettBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Olga BarbarashFederal State Budgetary Institution, Kemerovo, Russia.
Azfar ZamanFreeman Hospital and Newcastle University, Newcastle upon Tyne, UK.
Christina ChristerssonDepartment of Medical Science, Cardiology, Uppsala University, Uppsala, Sweden.
Songsak KiatchoosakunCardiology Unit, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
John AnonuevoDepartment of Medicine, University of the Philippines College of Medicine, Philippine General Hospital, Manila, Philippines.
Grzegorz OpolskiDepartment of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Mody F VaghaiwallaHeart Failure and Preventive Cardiology Programs, Department of Veterans Affairs Greater Los Angeles, University of California, Los Angeles, CA, USA.
Peter van der MeerDepartment of Cardiology, University Medical Center Groningen, Groningen, Netherlands.
Yinong ZhouNovartis Inc., East Hanover, NJ, USA.
Douglas L MannCardiovascular Division, Washington University, School of Medicine, St. Louis, MS, USA.
Lars KoberRigshospitalet, Blegdamsvej, University of Copenhagen, Copenhagen, Denmark.
Gabriel StegUniversity Paris-Cite Institute, University de France, Hospital Bichat, Paris, France.
Karola JeringBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ian KulacBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Carmine G De PasqualeDepartment of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, SA, Australia.
John J V McMurraySchool of Cardiovascular & Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Marc A PfefferBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
PARADISE‐MI Investigators and Committees

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe relationship between body mass index (BMI) and clinical outcomes in patients with cardiovascular disease, including acute heart failure (AHF) and acute myocardial infarction (AMI), remains debated. This study investigates the association between BMI and clinical outcomes within the PARADISE-MI cohort, while also evaluating the impact of angiotensin receptor-neprilysin inhibitor (ARNI) versus angiotensin-converting enzyme inhibitor (ACE-I) treatment on this relationship. METHODS AND

resultsThe analysis included 5589 patients from the PARADISE-MI study with available baseline BMI data. The cohort comprised patients with AMI and pulmonary congestion and/or left ventricular ejection fraction ≤40%. Patients were categorized into six World Health Organization BMI subgroups. The primary outcome of interest was the composite endpoint of cardiovascular death, heart failure (HF)-associated hospitalization, and outpatient symptomatic HF episodes. The mean baseline BMI of the cohort was 28.1 ± 5.0 kg/m

conclusionsIn AMI with AHF patients, the relationship between BMI and the primary composite outcome is non-linear, with the lowest event rates observed in overweight individuals. Outcomes and safety profiles for ARNI and ACE-I treatments were similar across BMI subgroups.

Indexed as

Angiotensin-Converting Enzyme InhibitorsBody Mass IndexHeart FailureMyocardial InfarctionStroke VolumeVentricular Function, LeftAgedAngiotensin Receptor AntagonistsFemaleHumansMaleMiddle AgedObesityTreatment OutcomeAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAcute heart failureAngiotensin‐converting enzyme inhibitorsAngiotensin receptor–neprilysin inhibitorBody mass indexObesity paradox

Identifiers

PMID39692068
PMCPMC11955312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.