Evidence map›Paper›PMID 39692026›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Mexican Health and Aging Study Biomarker and Genetic Data Profile.

Rafael Samper-Ternent, Jesús Daniel Zazueta-Borboa, Alejandra Michaels-Obregon, Dolly Reyes-Dumeyer, Sandra Barral, Giuseppe Tosto, Rebeca Wong

Abstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rafael Samper-TernentInstitute on Aging, UTHealth Houston, Houston, Texas, USA.ORCID 0000-0002-2250-9401
Jesús Daniel Zazueta-BorboaNetherlands Interdisciplinary Demographic Institute KNAW/University of Groningen, 2511 CV The Hague, The Netherlands.
Alejandra Michaels-ObregonDepartment of Population Health Sciences, UTHealth San Antonio, Texas, USA.
Dolly Reyes-DumeyerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA.
Sandra BarralTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA.ORCID 0000-0001-5623-4939
Giuseppe TostoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA.ORCID 0000-0001-7075-8245
Rebeca WongDepartment of Population Health Sciences, UTHealth San Antonio, Texas, USA.ORCID 0000-0001-7287-0660

Funding

The Mexican Health and Aging Study - IIR01AG018016 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rebeca Wong · 1999 to 2026
$22.6M
Genetics of Alzheimer's Disease in MexicoR56AG059756 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARRAL RODRIGUEZ, SANDRA, MAYEUX, RICHARD P · 2018 to 2019
$5.0M
MHAS Cognitive Aging Ancillary Study Administrative SupplementR01AG051158 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WONG, REBECA · 2015 to 2017
$1.1M
Instituto Nacional de Estadística y Geografía R01AG051158NIA NIH HHS R01 AG018016NIA NIH HHS R01AG018016NIA NIH HHS R01 AG051158NIA NIH HHS R56 AG059756NIH HHS
6 · The paper itself

Abstract

The Mexican Health and Aging Study (MHAS) is one of the largest ongoing longitudinal studies of aging in Latin America, with six waves over 20 years. MHAS includes sociodemographic, economic, and health data from a nationally representative sample of adults 50 years and older in urban and rural Mexico. MHAS is designed to study the impact of diseases on adults' health, function, and mortality. As Mexico is experiencing rapid population aging, providing adequate information to study this phenomenon is vital for designing and implementing public policies. The availability of biomarker and genetic data and longitudinal survey data elevates opportunities for research on aging in a low-middle-income country. This manuscript describes the profile of biomarkers and genetic data available in the MHAS study, including sample sizes and sociodemographic characteristics of participants who provided biospecimens for biomarker analyses, emphasizing recent genetic data. The sample size of individuals with anthropometric biomarkers was 2 707 (Wave 1-2001), 2 361 (Wave 2-2003), 2 086 (Wave 3-2012), and 2 051 (2016). Capillary blood samples were collected from 2 063 participants in 2012 (Wave 3) and 1 141 in 2016. Venous blood samples for blood-based biomarkers were collected from 2 003 participants in 2012 (Wave 3) and 752 in 2016. Venous blood samples were also collected for genetic data from 2 010 participants in 2012 (Wave 3) and 750 in 2016. A total of 7 821 participants provided saliva in 2018, and 2 671 provided hair in 2018. From these samples, a total of 7 204 have genome-wide genetic data, 8 600 have apolipoprotein-E genotype data, and 7 156 have genetic ancestry data.

Indexed as

AgingBiomarkersAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMexicoMiddle AgedBiomarkersAnthropometric measuresBiomarkersGenetic dataMexicoMHAS

Identifiers

PMID39692026
PMCPMC11653003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.