ArticleJournal of the American Heart Association2025
Prognostic Implications of Right Ventricular Dysfunction in Severe Degenerative Mitral Regurgitation.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Predicting adverse outcomes after cardiac surgery and structural interventions: the role of right ventricular function.Future cardiology · 2026Review
- Right ventricle to pulmonary artery coupling in patients with primary mitral regurgitation: association with outcome.European heart journal. Cardiovascular Imaging · 2026Article
- Echocardiographic and invasive RV-PA coupling predict mortality after edge-to-edge repair for degenerative mitral regurgitation, while pulmonary artery pulsatility index does not: a single-center observational study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Prognostic Implications of Cardiac Magnetic Resonance Imaging Characteristics in Primary Mitral Regurgitation.JACC. Advances · 2025Article
- Refining Prognostication and Therapeutic Guidance Through Advances in Right Heart Imaging Approaches.The Canadian journal of cardiology · 2025Review
- Right Ventricular Dysfunction in Degenerative Mitral Regurgitation: A Canary in the Coalmine?Journal of the American Heart Association · 2025Article
- Image-based, whole-system hemodynamic modeling of mitral regurgitation and its impact on the right ventricular function.Frontiers in cardiovascular medicine · 2025Article
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18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence and impact of right ventricular dysfunction (RVD) in degenerative mitral regurgitation (DMR) is unknown. We aimed to determine whether RVD assessed by echocardiography in routine clinical practice is independently associated with mortality in patients with DMR. METHODS AND
resultsWe used data from the MIDA-Q (Mitral Regurgitation International DAtabase-Quantitative) registry, which included patients with isolated DMR due to mitral valve prolapse from January 2003 to January 2020 from 5 tertiary centers across North America, Europe, and the Middle East. A cohort of 2917 (mean age: 66 years, 70.8% male patients, follow-up: 5.2 [3.3-8.3] years) consecutive patients with severe DMR was included and long-term mortality was analyzed. RVD, identified in 426 (14.6%) patients, was associated with reduced 8-year survival (55%±3% versus 77%±1%;
conclusionsRVD is observed in 14.6% of severe DMR and exhibits a powerful and independent association with excess mortality partially attenuated by mitral surgery. Therefore, assessment of right ventricular systolic function should be included in routine DMR evaluation and in the clinical decision-making process.
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