Evidence map›Paper›PMID 39691828›Full record

ArticleClinical kidney journal2024

Predictive value of residual active histologic lesions on renal flare in lupus nephritis patients with clinical remission.

Jinhua Hou, Dandan Liang, Songxia Quan, Zhangsuo Liu, Zhihong Liu

Abstract read
In one paragraph

Article in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinhua HouNational Clinical Research Center of Kidney Diseases, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Dandan LiangNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.ORCID https://orcid.org/0009-0007-3066-7112
Songxia QuanHenan Province Research Center for Kidney Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhangsuo LiuHenan Province Research Center for Kidney Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0002-2916-8371
Zhihong LiuNational Clinical Research Center of Kidney Diseases, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-6093-0726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Renal flare in lupus nephritis (LN) is a crucial contributing factor to poor kidney outcomes. This study aimed at evaluating the predictive value of residual active histologic lesions on renal flare in proliferative LN patients with clinical remission. Methods: We retrospectively enrolled LN patients with class III/IV ± V (biopsy 1) who had undergone a protocol repeat biopsy (biopsy 2) at 7.3 (IQR: 6.5, 8.4) months after induction therapy with clinical remission and experienced renal flare within 3 years or had been followed up for at least 3 years without renal flare after biopsy 2 with maintenance therapy from two kidney units in China. Results: A total of 114 eligible patients were included, 28 (24.6%) of whom developed a renal flare. Activity index (AI) at biopsy 2 was significantly associated with LN flare ( Conclusions: Renal flare in LN patients with clinical remission is strongly associated with the residual active histologic lesions.

Indexed as

histologic activitykidney biopsylupus nephritisrenal flare

Identifiers

PMID39691828
PMCPMC11650015

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