Evidence map›Paper›PMID 39691712›Full record

ArticleFrontiers in immunology2024

Human airway epithelium controls

Philipp Grubwieser, Nina Böck, Erika Kvalem Soto, Richard Hilbe, Patrizia Moser, Markus Seifert, Stefanie Dichtl, Miriam Alisa Govrins, Wilfried Posch, Thomas Sonnweber and 4 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Philipp Grubwieser *Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
Nina Böck *Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.
Erika Kvalem SotoBiocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.
Richard HilbeDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
Patrizia MoserINNPATH, Innsbruck Medical University Hospital, Innsbruck, Austria.
Markus SeifertDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
Stefanie DichtlInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Miriam Alisa GovrinsInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Wilfried PoschInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Thomas SonnweberDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
Manfred NairzDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
Igor TheurlDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
Zlatko TrajanoskiBiocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.
Günter WeissDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Airway epithelial cells play a central role in the innate immune response to invading bacteria, yet adequate human infection models are lacking. Methods: We utilized mucociliary-differentiated human airway organoids with direct access to the apical side of epithelial cells to model the initial phase of Results: Immunofluorescence of infected organoids revealed that Discussion: Our findings highlight the critical role of epithelial-derived iNOS in host defence against

Indexed as

Nitric Oxide Synthase Type IIOrganoidsPseudomonas aeruginosaPseudomonas InfectionsRespiratory MucosaEpithelial CellsHost-Pathogen InteractionsHumansImmunity, InnateNitric OxideNitric OxideNitric Oxide Synthase Type IINOS2 protein, humanairway epitheliaairway organoidsinnate immunityiNOSPseudomonas aeruginosa

Identifiers

PMID39691712
PMCPMC11649544

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.