Evidence map›Paper›PMID 39691698›Full record

ArticleFrontiers in cellular and infection microbiology2024

Swine IFN cocktail can reduce mortality and lessen the tissue injury caused by African swine-fever-virus-infected piglets.

Yitong Jiang, Fei Jiang, Wenzhu Zhai, Ying Huang, Zhongbao Pang, Chunhao Tao, Zhen Wang, Yuheng He, Yuanyuan Chu, Hongfei Zhu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yitong Jiang *Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Fei Jiang *China Animal Disease Control Center, Beijing, China.
Wenzhu ZhaiInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Ying HuangInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Zhongbao PangInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Chunhao TaoInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Zhen WangInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Yuheng HeInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Yuanyuan ChuInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Hongfei ZhuInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Jiajun WuChina Animal Disease Control Center, Beijing, China.
Hong JiaInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever (ASF), a highly virulent viral infection, poses a significant threat to the global pig industry. Currently, there are no commercially available vaccines against ASF. While the crucial role of interferon (IFN) in combating viral infections is well-established, its impact on the clinical signs and mortality rates of ASF remains unclear. In this study, swine IFN-α2, IFN-γ, and IFN-λ3 were fused with the Fc segment of immunoglobulin G (IgG) and expressed in mammalian cells (293T), and the antiviral efficacy were detected by VSV-3D4/2 and VSV-PK15 systems. Then, the interferon stimulating genes (ISGs) induced by IFNs-hFc in 3D4/2 cells were determined by qRT-PCR. Also, the preventive potential of the interferon (IFN) cocktail (a mixture of IFNα2-hFc, IFNγ-hFc, and IFNλ3-hFc) were evaluated

Indexed as

African Swine FeverAfrican Swine Fever VirusAntiviral AgentsInterferonsAnimalsCell LineHEK293 CellsHumansInterferon-gammaSwineViral LoadAntiviral AgentsInterferon-gammaInterferonsAfrican swine fevercocktailinterferonmortalityviral load

Identifiers

PMID39691698
PMCPMC11649406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.