Evidence map›Paper›PMID 39691690›Full record

ArticleFood & nutrition research2024

Effect of oleocanthal-rich olive oil on postprandial oxidative stress markers of patients with type 2 diabetes mellitus.

Maria Efthymia Katsa, Andrea Paola Rojas Gil, Evangelia-Mantelena Makri, Spyridon Papadogiannis, Anastasios Ioannidis, Marianna Kalliostra, Kleopatra Ketselidi, Panagiotis Diamantakos, Eleni Melliou, Prokopios Magiatis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food & nutrition research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Efthymia KatsaDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece.
Andrea Paola Rojas GilLaboratory of Biology and Biochemistry, Department of Nursing, Faculty of Health Sciences, University of Peloponnese, Tripoli, Greece.
Evangelia-Mantelena MakriDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece.
Spyridon PapadogiannisLaboratory of Biology and Biochemistry, Department of Nursing, Faculty of Health Sciences, University of Peloponnese, Tripoli, Greece.
Anastasios IoannidisLaboratory of Biology and Biochemistry, Department of Nursing, Faculty of Health Sciences, University of Peloponnese, Tripoli, Greece.
Marianna KalliostraDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece.
Kleopatra KetselidiDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece.
Panagiotis DiamantakosLaboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Ka-podistrian University of Athens, Athens, Greece.
Eleni MelliouLaboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Ka-podistrian University of Athens, Athens, Greece.
Prokopios MagiatisLaboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Ka-podistrian University of Athens, Athens, Greece.
Tzortzis NomikosDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 2 diabetes mellitus (T2DM) is characterized by postprandial dysmetabolism, which has been linked to post-meal redox disturbances. Oleocanthal (OO), one of the most potent bioactive phenols of extra virgin olive oil, has shown redox modulating properties in vitro. However, its acute, in vivo antioxidant properties have never been studied before. Objective: The aim of this study was to investigate the kinetics of five redox markers (Thiobarbituric acid-reactive substances [TBARS] and glutathione peroxidase activity in serum-GPx3 and erythrocytes (GPx1), protein carbonyls in serum) after the consumption different meals. Design: Five different isocaloric meals comprised of white bread and butter (BU) or butter plus ibuprofen (BU-IBU) or olive oil poor in OO or olive oils containing 250 and 500 mg/Kg of oleocanthal (OO250 and OO500, respectively). We hypothesized that OO-rich olive oil will reduce postprandial oxidative stress in T2DM patients compared to other lipid sources. This study involved 10 patients with T2DM and had a cross-over design. Results: The comparison of incremental Area Under Curves (iAUCs) has shown that OO-rich olive oils were able to alleviate the increments of thiobarbituric acid-reactive substances (TBARS) and GPx3 and induce a higher red blood cells (RBCs) GPx1 activity compared to OO ( Discussion: This study demonstrates for the first time that, apart from its anti-inflammatory and antiplatelet properties, OO can also exert acute antioxidant effects. Conclusion: This finding emphasizes the health benefits of extra virgin olive oil, particularly those with a high OO content, for T2DM patients.

Indexed as

glutathione peroxidasesibuprofeninflammationplateletspostprandial dysmetabolismprotein carbonylsred blood cellsthiobarbituric acid-reactive substances

Identifiers

PMID39691690
PMCPMC11650448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.