Evidence map›Paper›PMID 39691557›Full record

ArticleNanoscale advances2025

Polynorepinephrine nanoparticles activate vascular smooth muscle alpha-1 adrenergic receptors.

Vinayaraj Ozhukil Kollath, Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Simon A Hirota, Morley D Hollenberg, Kunal Karan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vinayaraj Ozhukil KollathDepartment of Chemical and Petroleum Engineering, University of Calgary Calgary AB Canada kkaran@ucalgary.ca.
Vivek Krishna Pulakazhi VenuDepartment of Physiology & Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine Calgary AB Canada mhollenb@ucalgary.ca.
Mahmoud SaifeddineDepartment of Physiology & Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine Calgary AB Canada mhollenb@ucalgary.ca.
Koichiro MiharaDepartment of Physiology & Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine Calgary AB Canada mhollenb@ucalgary.ca.
Simon A HirotaDepartment of Physiology & Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine Calgary AB Canada mhollenb@ucalgary.ca.
Morley D HollenbergDepartment of Physiology & Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Disease, University of Calgary Cumming School of Medicine Calgary AB Canada mhollenb@ucalgary.ca.
Kunal KaranDepartment of Chemical and Petroleum Engineering, University of Calgary Calgary AB Canada kkaran@ucalgary.ca.ORCID https://orcid.org/0000-0001-5432-8050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biocompatible polymeric nanoparticles (NPs) as carriers for therapeutic agents with multifunctional activities have received unprecedented attention for a variety of bio-pharmaceutical applications. We describe the synthesis, the fluorescence properties, the bio-compatible nature and the alpha-1 adrenergic receptor bio-activity of engineered quantum dot-like polynorepinephrine (PNE) NPs. The spherical PNE NPs, which are internalized in smooth muscle cells

Identifiers

PMID39691557
PMCPMC11647915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.