Evidence map›Paper›PMID 39691536›Full record

ArticleACS medicinal chemistry letters2024

Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design.

Ross P Hryczanek, Andrew S Hackett, Paul Rowland, Chun-Wa Chung, Máire A Convery, Duncan S Holmes, Jonathan P Hutchinson, Semra Kitchen, Justyna Korczynska, Robert P Law and 18 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Ross P HryczanekGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.ORCID https://orcid.org/0009-0003-7005-4477
Andrew S HackettGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Paul RowlandGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Chun-Wa ChungGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.ORCID https://orcid.org/0000-0002-2480-3110
Máire A ConveryGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Duncan S HolmesGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Jonathan P HutchinsonGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Semra KitchenGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Justyna KorczynskaGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Robert P LawGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.ORCID https://orcid.org/0000-0002-2585-4585
Jonathan D LeaGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
John LiddleGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Richard LonsdaleGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.ORCID https://orcid.org/0000-0001-9160-4659
Margarete NeuGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Leng NickelsGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Alex PhillipouGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
James E RowedderGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Jessica L SchneckGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Paul Scott-StevensGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Hester SheehanGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Chloe L TaylerGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Ioannis TemponerasNational Center for Scientific Research "Demokritos", Agia Paraskevi, Attiki 15341, Greece.
Christopher P TinworthGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.ORCID https://orcid.org/0000-0002-2756-707X
Ann L WalkerGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Justyna Wojno-PiconGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
Robert J YoungGSK, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.ORCID https://orcid.org/0000-0002-7763-0575
David M LindsayDepartment of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, U.K.ORCID https://orcid.org/0000-0003-4498-5094
Efstratios StratikosNational Center for Scientific Research "Demokritos", Agia Paraskevi, Attiki 15341, Greece.ORCID https://orcid.org/0000-0002-3566-2309

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoplasmic reticulum aminopeptidase 1 (ERAP1) cleaves the

Identifiers

PMID39691536
PMCPMC11647717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.