Evidence map›Paper›PMID 39691471›Full record

ArticleJournal of molecular and cellular cardiology plus2024

Conditional ablation of MCU exacerbated cardiac pathology in a genetic arrhythmic model of CPVT.

Arpita Deb, Brian D Tow, Jie Hao, Branden L Nguyen, Valeria Gomez, James A Stewart, Ashley J Smuder, Bjorn C Knollmann, Ying Wang, Bin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arpita DebDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Brian D TowDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Jie HaoPlant Pathology Department, University of Florida, Gainesville, FL 32611, USA.
Branden L NguyenDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Valeria GomezFood Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
James A StewartSchool of Pharmacy, Department of BioMolecular Sciences, University of Mississippi, Oxford, MS 38677, USA.
Ashley J SmuderDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Bjorn C KnollmannDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Ying WangDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Bin LiuDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.

Funding

Breathing Research and Therapeutics (BREATHE)T32HL134621 · NHLBI · UNIVERSITY OF FLORIDA · PI Gordon S. Mitchell · 2017 to 2026
$3.4M
Role of SR-mitochondria interplay in calcium-dependent arrhythmiasR01HL166169 · NHLBI · UNIVERSITY OF FLORIDA · PI Bin Liu · 2024 to 2026
$1.4M
Exploring the role of mitochondria in dysregulated calcium handling in diseased heartsR15HL154073 · NHLBI · MISSISSIPPI STATE UNIVERSITY · PI LIU, BIN · 2021 to 2021
$423k
NHLBI NIH HHS R01 HL166169NHLBI NIH HHS R15 HL154073NHLBI NIH HHS T32 HL134621
6 · The paper itself

Abstract

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca Methods and results: The Mitochondrial Ca Conclusions: We present genetic evidence that mitochondria play a protective role in CPVT. MCU-dependent Ca

Indexed as

Ca2+-dependent cardiomyopathyRyR2 leak

Identifiers

PMID39691471
PMCPMC11651627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.