ReviewIbrain2024
Global, regional, and national burdens of Alzheimer's disease and other forms of dementia in the elderly population from 1999 to 2019: A trend analysis based on the Global Burden of Disease Study 2019.
Review in Ibrain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of exercise on cognitive function in older patients with Alzheimer's disease: a meta-regression and meta-analysis.Frontiers in public health · 2026Pooled it
- Silent brain infarction is associated with executive dysfunction in community-dwelling older adults: the Sefuri-Yoshinogari study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Effects of Positive Airway Pressure Therapy on Cognitive Function in Patients with Obstructive Sleep Apnea: A Prospective Observational Study Protocol.Life (Basel, Switzerland) · 2026Article
- Network pharmacology approach to unravel the neuroprotective potential of natural products: a narrative review.Molecular diversity · 2026Review
- Global Burden of Alzheimer's Disease and Other Dementias during 1990-2021: A Global Burden of Disease and Risk Factors Study 2021-Based Study.Neuroepidemiology · 2026Article
- Transitions in Sarcopenia Status and Cognitive Trajectories Among Middle-Aged and Older Adults in China: Longitudinal Cohort Study.JMIR aging · 2025Article
- Application of mesenchymal stem cells in ferroptosis-related diseases.Journal of molecular medicine (Berlin, Germany) · 2025Review
- [Disease-modifying therapy with lecanemab for early Alzheimer's dementia].Fortschritte der Neurologie-Psychiatrie · 2025Review
- Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study.The Journal of frailty & aging · 2025Observational
- Natural Neuroinflammatory Modulators: Therapeutic Potential of Fungi-Derived Compounds in Selected Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2025Review
- Alzheimer's disease and dementia in Japan: Epidemiological trends, regional disparities, and future projections.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Burden of risk factors attributable to Alzheimer's disease and other dementia and its relationship with the Socio-Demographic index in Asia.BMC neurology · 2025Article
- Combination of Epigallocatechin-3-Gallate and Tramiprosate Prevent Accumulation of Intracellular Aβ and Dysfunctional Autophagy-Lysosomal Pathway at Earliest Stage of Transdifferentiation of Mesenchymal Stromal Cells into PSEN1 E280A Cholinergic-like Neurons.International journal of molecular sciences · 2025Article
- Alzheimer's Prediction Methods with Harris Hawks Optimization (HHO) and Deep Learning-Based Approach Using an MLP-LSTM Hybrid Network.Diagnostics (Basel, Switzerland) · 2025Article
- Peruvian validation and standardization of the TabCAT-brain health assessment.Frontiers in public health · 2025Article
- Association of zinc deficiency and risk of new-onset dementia: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Review
- Multidimensional burden of caregivers of Alzheimer's disease and related dementia in China: A nationwide cross-sectional study.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia represents a significant health issue, afflicting both patients and their families. To assess the global trends in the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of Alzheimer's disease (AD) and other dementias in the elderly population, the Global Burden of Disease Study (1999-2019) was used. The average annual percentage change (AAPC) was estimated using linear regression. Stratified analysis of the global trends by age, sex, region, national level, and social development index (SDI) were also performed. The global incidence of AD and other dementias increased from 507.96 per 100,000 in 1990 to 569.39 per 100,000 in 2019, showing a significant increase in this period. In males, the incidence increased from 387.56 per 100,000 population in 1990 to 462.40 per 100,000 in 2019 (AAPC = 0.61), whereas females experienced a slower rise (AAPC = 0.31) and had a higher incidence in 2019 (662.93 per 100,000 population). The most significant increase was observed in individuals aged 60-64 and those in the middle-SDI quintile. Regionally, the high-income Asia Pacific had the highest incidence (890.01 per 100,000 population) and DALYs (3043.86 per 100,000) in AD and other dementias in 2019. As for national trends, Japan had the most pronounced increase in the incidence and DALYs of AD and other dementias during the 1990-2019 period. These findings highlight the growing burden of dementias on life expectancy at a population level, which is significant for healthcare professionals and decision-makers to conduct the ongoing debate on the policy of AD and other dementias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.