ArticleIJID regions2024
Initial HIV-1 viral load in French Guiana: Factors associated with viral load set point differences.
Article in IJID regions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
Objectives: HIV viral load set points may vary between virus subtypes and host characteristics. The HIV epidemic in French Guiana entails a mix of viruses and populations of cosmopolitan origins. In this epidemiological context, we aimed to determine whether, at the scale of our territory, we could identify differences in HIV-1 viral load setpoints in our hospital cohort. Methods: The French Guiana hospital cohort was retrospectively analyzed between 1992 and 2023. Bootstrapped (100 replications) quantile (median) regression modeled the initial HIV-1 viral load with age, sex, nationality, and cluster of differentiation (CD) 4 count at diagnosis as independent variables. Results: After adjusting for period of analysis and CD4 count at diagnosis, bootstrapped quantile regression (median) showed that Haitians (minus 20,088 copies, Conclusions: We show some significant differences in the viral load set point of different groups. For nationalities, we are inclined to attribute this to differences in the frequency of infecting subtypes. This suggests that models of incidence or date of infection based on CD4 decline may be distorted by this situation.
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