Evidence map›Paper›PMID 39691265›Full record

ArticleEJHaem2024

Congestive heart failure after anthracycline-containing treatment for Hodgkin lymphoma: A Swedish matched cohort study.

Joachim Baech, Tarec Christoffer El-Galaly, Joshua P Entrop, Ingrid Glimelius, Daniel Molin, Sissel Johanne Godtfredsen, Michael J Crowther, Karin E Smedby, Sandra Eloranta, Caroline E Dietrich

Abstract read
In one paragraph

Article in EJHaem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joachim BaechDepartment of Hematology Clinical Cancer Research Center Aalborg University Hospital Aalborg Denmark.ORCID https://orcid.org/0000-0001-8848-4879
Tarec Christoffer El-GalalyDepartment of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet Stockholm Sweden.
Joshua P EntropDepartment of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0003-1614-8096
Ingrid GlimeliusDepartment of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0001-6158-3041
Daniel MolinDepartment of Immunology Genetics, and Pathology Cancer Immunotherapy Uppsala University Uppsala Akademiska Hospital Uppsala Sweden.
Sissel Johanne GodtfredsenDepartment of Cardiology Aalborg University Hospital Aalborg Denmark.ORCID https://orcid.org/0000-0002-1049-9285
Michael J CrowtherRed Door Analytics AB Stockholm Sweden.
Karin E SmedbyDepartment of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet Stockholm Sweden.
Sandra ElorantaDepartment of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet Stockholm Sweden.
Caroline E DietrichDepartment of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0001-8231-8183

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Congestive heart failure (CHF) is a known complication after anthracyclines and radiotherapy for classical Hodgkin lymphoma (cHL). Contemporary cHL treatment may be associated with less risk because radiotherapy use and techniques have changed substantially over time. Methods: In this study, Swedish cHL patients diagnosed in 2000-2018, and treated with adriamycin [doxorubicin], bleomycin, vinblastine, and dacarbazine (ABVD) or bleomycin, etoposide, Adriamycin [doxorubicin], cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP), were matched 1:10 to the general population on birth year and sex to investigate relative rates and cumulative risks of CHF. Results: A total of 1994 cHL patients were included, with a median age of 34 years. The median follow-up was 8.1 years. The CHF rate was higher for patients versus comparators (adjusted hazard ratio [HR] = 3.02, 95% confidence interval [CI]: 2.26-4.02). Patients treated with ≤200 mg/m Conclusion: These findings highlight that cHL survivors still face a substantial excess risk of CHF in the modern treatment era and that focus on cardiovascular health remains relevant.

Identifiers

PMID39691265
PMCPMC11647705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.