Evidence map›Paper›PMID 39691250›Full record

ArticleEJHaem2024

Isolated thrombocytopenia in pregnancy: A monocentric retrospective study of 63 pregnancies in 59 women.

Giulia Freddi, Enea Parimbelli, Federico Vai, Silvana Quaglini, Valeria Bozzi, Serena Barozzi, Fausta Beneventi, Irene De Maggio, Chiara Cavagnoli, Antonio Di Sabatino and 2 more

Abstract read
In one paragraph

Article in EJHaem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giulia FreddiDepartment of Internal Medicine and Therapeutics University of Pavia Pavia Italy.
Enea ParimbelliDepartment of Electrical, Computer and Biomedical Engineering University of Pavia Pavia Italy.
Federico VaiDepartment of Internal Medicine and Therapeutics University of Pavia Pavia Italy.
Silvana QuagliniDepartment of Electrical, Computer and Biomedical Engineering University of Pavia Pavia Italy.
Valeria BozziObsterics and Gynecology Unit IRCCS Policlinico San Matteo Foundation Pavia Italy.
Serena BarozziObsterics and Gynecology Unit IRCCS Policlinico San Matteo Foundation Pavia Italy.
Fausta BeneventiObsterics and Gynecology Unit IRCCS Policlinico San Matteo Foundation Pavia Italy.
Irene De MaggioObsterics and Gynecology Unit IRCCS Policlinico San Matteo Foundation Pavia Italy.
Chiara CavagnoliObsterics and Gynecology Unit IRCCS Policlinico San Matteo Foundation Pavia Italy.
Antonio Di SabatinoDepartment of Internal Medicine and Therapeutics University of Pavia Pavia Italy.
Patrizia NorisDepartment of Internal Medicine and Therapeutics University of Pavia Pavia Italy.ORCID https://orcid.org/0000-0002-3374-7325
Federica MelazziniDepartment of Internal Medicine and Therapeutics University of Pavia Pavia Italy.ORCID https://orcid.org/0000-0003-2638-4308

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombocytopenia during pregnancy is often thought to be associated with severe bleeding manifestations. Three are the main disorders associated with this condition: gestational thrombocytopenia (GT), immune thrombocytopenia (ITP), and inherited thrombocytopenias (ITs). Reaching the correct diagnosis of this condition has relevant therapeutic and outcome implications. We performed a retrospective, observational, monocentric study enrolling 59 consecutive women with isolated thrombocytopenia, attended to our referral center in the last 3 years. Together with personal and family history, platelet (PLT) count trend and mean platelet volume (MPV) in pregnancy are helpful for the diagnosis, with the highest PLT count in GT and lowest in ITs, with different timing of count decrease. MPV is significantly increased in both ITs and ITP. Misdiagnosis with ITP was responsible for unnecessary and unsuccessful therapy in some GT or ITs pregnant women, determining relevant side effects. Excluding inherited platelet function disorders (IPFDs), the bleeding risk for mother with thrombocytopenia and their newborns is similar to the general population. Vaginal delivery is associated with a lower risk of bleeding than cesarean section and therefore is preferable whenever obstetrical-gynecological conditions permit.

Indexed as

bleeding disordersplateletspregnancythrombocytopenia

Identifiers

PMID39691250
PMCPMC11647692

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.