ArticleThe Journal of clinical endocrinology and metabolism2025
Adult-based Genetic Risk Scores for Insulin Resistance Associate With Cardiometabolic Traits in Children and Adolescents.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Adult-based Genetic Risk Scores for Insulin Resistance Associate With Cardiometabolic Traits in Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2025Article
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13 authors.
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Abstract
contextInsulin resistance (IR) is a key factor in the development of cardiometabolic diseases. While genetic risk scores (GRSs) for IR have been developed and validated in adult populations, it is unclear if they can be used for risk assessment in youth.
objectiveOur objective was to investigate whether adult-derived GRSs for IR associate with cardiometabolic traits in children and adolescents.
methodsWe studied a group of children and adolescents with obesity (n = 1680) and a group without obesity (n = 1804). We constructed 3 GRSs based on fasting (IR-GRS27), oral glucose tolerance test (IR-GRS8), and IR-related phenotypes (IR-GRS51) from previous genome-wide association studies. Using an additive genetic model, we calculated weighted GRSs and analyzed their associations with cardiometabolic traits using linear and logistic regression models.
resultsThe IR-GRS27 was associated with higher serum concentrations of fasting insulin, C-peptide, triglycerides (TG), gamma-glutamyl transferase and alanine aminotransferase (ALT), and homeostatic model assessment of insulin resistance. The IR-GRS27 was furthermore associated with a higher prevalence of IR and ALT. IR-GRS51 was associated with higher TG and lower high-density lipoprotein cholesterol, while IR-GRS8 associated with lower total cholesterol, low-density lipoprotein cholesterol, and increased ALT. IR-GRS27 and IR-GRS8 were additionally associated with a higher prevalence of IR and steatotic liver disease, respectively.
conclusionAdult-derived GRSs for IR are significantly associated with cardiometabolic traits in children and adolescents. If validated in independent study samples, our findings suggest the contribution of adult-based GRSs in assessing IR-related cardiometabolic risk in youth.
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