Evidence map›Paper›PMID 39690974›Full record

ArticleChemical communications (Cambridge, England)2025

Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy.

Mayesha B Mustafa, Jinchao Lou, Miranda A Phillips, Robert F Turner, Joshua A Baccile, Michael D Best

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mayesha B MustafaDepartment of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA. mdbest@utk.edu.
Jinchao LouDepartment of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA. mdbest@utk.edu.ORCID http://orcid.org/0000-0001-5064-761X
Miranda A PhillipsDepartment of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA. mdbest@utk.edu.ORCID http://orcid.org/0000-0003-2649-5657
Robert F TurnerDepartment of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA. mdbest@utk.edu.
Joshua A BaccileDepartment of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA. mdbest@utk.edu.
Michael D BestDepartment of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA. mdbest@utk.edu.ORCID http://orcid.org/0000-0001-8737-5910

Funding

Liposome Targeting and Triggered Release Driven by Reactive Oxygen SpeciesR15GM146193 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI BEST, MICHAEL D. · 2022 to 2022
$459k
NIGMS NIH HHS R15 GM146193
6 · The paper itself

Abstract

We report a charge balance strategy for reactive oxygen species (ROS)-triggered activation of liposome cell delivery by unmasking cationic membranes. Zeta potential experiments, microplate-based vesicle interaction assays, and cellular delivery studies confirmed that modification of anionic lipid 1 by ROS led to the uncaging of cationic liposomes, thereby driving cellular association.

Indexed as

LiposomesReactive Oxygen SpeciesCationsHumansCationsLiposomesReactive Oxygen Species

Identifiers

PMID39690974
PMCPMC11869113

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.