SynthesisActa paediatrica (Oslo, Norway : 1992)2025
Short- versus standard-course antimicrobial therapy for children with urinary tract infection: A meta-analysis.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Short- versus standard-course antimicrobial therapy for children with urinary tract infection: A meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Urinary tract infections in children.Nature reviews. Urology · 2026Review
- Antibiotic Stewardship in Pediatric Urinary Tract Infections: Current Evidence and Practical Strategies.Antibiotics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
aimTo determine if short- (2-5 days) course antimicrobials are as effective as standard- (6-14 days) course antimicrobials in the treatment of symptomatic UTI in children.
methodsMEDLINE and EMBASE were searched from their origin to January 2024. We only considered randomised controlled trials in children <18 years of age. The main outcomes of interest were UTI or bacteriuria at the end of therapy.
resultsNine studies were included. Compared to children treated with a standard course of antimicrobials, those treated with shortened courses of antimicrobials did not have significantly different risks of UTI at the end of therapy (risk difference 2.2%, CI: 0.0-4.3). Risk of bacteriuria at end of therapy (RD = 8.7%, CI: 5.3-12.2) was slightly higher in children treated with shorter courses. In children with fever at baseline (two studies), there was no significant difference in risk between short and standard duration treatment (RD = 0.4%, CI: -2.8 to 3.6).
conclusionIn children without fever at the time of presentation, treatment with shorter courses of antimicrobials appears reasonable. More studies of febrile children are needed before shorter courses could be recommended for febrile children.
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Registered trials
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