ArticleJournal of the American Geriatrics Society2025
Associations between multimorbidity and kidney function decline in old age: A population-based cohort study.
Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Patterns of multimorbidity and in-hospital kidney function decline in older adults: a latent class analysis of three acute-care cohorts.Internal and emergency medicine · 2026Article
- Short-Term Effects of Structured Physical Activity With or Without Dietary Counselling in Early-Stage Chronic Kidney Disease Managed in Primary Care: A Non-Randomised Controlled Study.Journal of clinical medicine · 2026Article
- Educational Interventions on Chronic Kidney Disease for Care Home Staff: An Empty Scoping Review.Nursing reports (Pavia, Italy) · 2026Review
- Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project.BMC medicine · 2026Article
- Shared and specific blood biomarkers for multimorbidity.Nature medicine · 2026Article
- Psychiatric Comorbidity and Metabolic Heterogeneity in a Multimorbid Cardiometabolic Cohort: An Exploratory Real-World Analysis.Healthcare (Basel, Switzerland) · 2025Article
- Associations of chronic disease status and the risk of new-onset hip or femoral fractures in older population.Journal of orthopaedics · 2025Article
- Multimorbidity clusters: translating research evidence into actionable interventions.European geriatric medicine · 2025Article
- Associations between multimorbidity and kidney function decline in old age: A population-based cohort study.Journal of the American Geriatrics Society · 2025Article
- Health-Related Quality of Life in Patients End-Stage Kidney Disease with Hypertension: Hemodialysis Vs Continuous Ambulatory Peritoneal Dialysis Using EQ-5D-5L at a Tertiary Center in Indonesia.International journal of nephrology and renovascular disease · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundIndividual chronic conditions have been linked to kidney function decline; however, the role of multimorbidity (the presence of ≥2 conditions) and multimorbidity patterns remains unclear.
methodsA total of 3094 individuals from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) were followed for 15 years. Multimorbidity was operationalized as the number of chronic conditions and multimorbidity patterns identified using latent class analysis (LCA). Joint models and Cox regression models were used to explore the associations between multimorbidity, and subsequent absolute and relative (≥25% decline from baseline) changes, respectively, in the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Berlin Initiative Study equation.
resultsMean age of the sample was 73.9, and 87% had multimorbidity. There was an independent dose-response relationship between the number of chronic conditions, and absolute (β [95% confidence interval, CI] = -0.05 [-0.07; -0.03]) and relative (hazard ratio, HR [95% CI] = 1.23 [1.17; 1.29]) declines in eGFR. Five patterns of multimorbidity were identified. The Unspecific, low burden pattern had the lowest morbidity burden and was used as the reference category. The Unspecific, high burden, and Cardiometabolic patterns showed accelerated absolute (β [95% CI] = -0.15 [-0.26; -0.05] and -0.77 [-0.98; -0.55], respectively) and relative (HR [95% CI] = 1.45 [1.09; 1.92] and 3.45 [2.27; 5.23], respectively) declines. Additionally, the Cognitive and Sensory pattern showed accelerated relative decline (HR [95% CI] = 1.53 [1.02; 2.31]). No associations were found for the Psychiatric and Respiratory pattern.
conclusionMultimorbidity is strongly associated with accelerated kidney function decline in older age. Individuals with cardiometabolic multimorbidity exhibit a particularly increased risk. Increased monitoring and timely interventions may preserve kidney function and reduce cardiovascular risks in individuals presenting with conditions that are characteristic of high-risk multimorbidity patterns.
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