Evidence map›Paper›PMID 39690832›Full record

ArticlePediatric blood & cancer2025

Kidney Function and Body Composition in Adult Survivors of Unilateral, Non-Syndromic Wilms Tumor: A Report From the St. Jude Lifetime Cohort Study.

Daniel M Green, Kendrick Li, Sue C Kaste, Kirsten K Ness, Matthew J Krasin, Lu Xie, Carmen L Wilson, DeoKumar Srivastava, Dennis W Jay, Andrew M Davidoff and 10 more

Abstract read
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Daniel M GreenDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-5156-5410
Kendrick LiDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Sue C KasteDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-2084-1507
Matthew J KrasinDepartment of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Lu XieDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Carmen L WilsonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0001-7636-065X
DeoKumar SrivastavaDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Dennis W JayDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Andrew M DavidoffDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Rima S ZahrDepartment of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-3631-7195
Siddhant TanejaDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kyla C SheltonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jennifer Q LanctotCancer Center Administration, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Stephanie B DixonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0003-3901-3274
Matthew J EhrhardtDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Daniel A MulrooneyDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Gregory T ArmstrongDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0001-8722-4207
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Melissa M HudsonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
The St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9M
American Lebanese-Syrian Associated CharitiesNCI NIH HHS P30 CA021765NCI NIH HHS P30 CA21765NCI NIH HHS U01 CA195547
6 · The paper itself

Abstract

backgroundThe relationships among treatment exposures, body composition, and estimated glomerular filtration rate (eGFR) in adult survivors of Wilms tumor have not been well studied.

methodsWe evaluated body composition with dual-energy x-ray absorptiometry (DXA) and eGFR with the updated Chronic Kidney Disease Epidemiology Collaboration equations (creatinine only-eGFR

resultsWART was associated with a lower relative total (p = 0.004) and trunk (p < 0.001) lean mass, eGFR

conclusionsWART is associated with lower relative total and trunk lean mass Z-scores and eGFR, regardless of the equation used, and is lower in survivors treated with WART compared to unirradiated survivors of unilateral, non-syndromic WT. Assessments using other GFR measures may provide greater insight into the mechanism and magnitude of kidney function loss among WART-treated WT survivors.

Indexed as

Body CompositionCancer SurvivorsGlomerular Filtration RateKidneyKidney NeoplasmsWilms TumorAbsorptiometry, PhotonAdolescentAdultCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisestimated glomerular filtration ratekidney functionradiation therapyrelative lean massWilms tumor

Identifiers

PMID39690832
PMCPMC11867057

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.