Evidence map›Paper›PMID 39690363›Full record

ArticleInflammopharmacology2025

Anti-inflammatory effect of nestorone in a lipopolysaccharide-induced acute lung injury model through regulation of the TLR-4/Myd88/NF-κB signaling pathway.

Aying Ma, Jieyun Zhou, Hui Zou, Li Yuan, Ruihua Zhong, Yan Zhu, Chao Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aying Ma *Department of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jieyun Zhou *NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China.
Hui ZouDepartment of Gastroenterology, Jingdezhen Hospital of Traditional Chinese Medicine, Jingdezhen, 333000, China.
Li YuanDepartment of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Ruihua ZhongNHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China.
Yan ZhuNHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200032, China. zhuyan@sippr.org.
Chao GaoDepartment of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. gao.chao@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-8381-7416

Funding

National Key Research and Development Program of China 2023YFC3402700Natural Science Foundation of Shanghai Municipality 22ZR1411200Youth Foundation of Zhongshan Hospital Fudan University 2023ZSQN26
6 · The paper itself

Abstract

Progesterone plays a crucial and indispensable role in regulating immunity and attenuating inflammation. Nestorone

Indexed as

Acute Lung InjuryAnti-Inflammatory AgentsToll-Like Receptor 4A549 CellsAnimalsCytokinesDisease Models, AnimalHumansInflammationLipopolysaccharidesMacrophagesMaleMiceMice, Inbred C57BLMyeloid Differentiation Factor 88NF-kappa BAnti-Inflammatory AgentsCytokinesLipopolysaccharidesMyeloid Differentiation Factor 88NF-kappa BToll-Like Receptor 4A549Acute lung injuryAnti-inflammatoryNestoroneReporter cellToll-like receptor

Identifiers

PMID39690363
PMCPMC11913939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.