Trial reportInflammopharmacology2025
Effects of tranexamic acid on postoperative knee activity and stress, and inflammation cytokines in patients undergoing total knee arthroplasty.
Trial report in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Repurposing tranexamic acid as an anticancer drug: a systematic review and meta-analysis.Journal of cancer research and clinical oncology · 2025Pooled it
- Key Inflammatory Pathways, Biomarkers, and Targeted Management Strategies in Primary Total Joint Arthroplasty: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Evidence on oral tranexamic acid versus intravenous tranexamic acid for perioperative blood management in total knee arthroplasty: a systematic review and meta-analysis.EFORT open reviews · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTotal knee arthroplasty (TKA) is an effective treatment for knee osteoarthritis, with postoperative bleeding and the inflammation-stress response being key factors that influence its outcomes. Tranexamic acid (TXA), an antifibrinolytic agent, has demonstrated efficacy in controlling perioperative bleeding. This study was to examine the effects of different doses of TXA on postoperative knee mobility and the inflammation-stress response in patients undergoing TKA
methodsNinety-eight patients undergoing unilateral TKA were randomly grouped based on the dose of TXA administered: 10 mg/kg (AG), 15 mg/kg (BG), and 20 mg/kg (CG). The bleeding, coagulation function, inflammation-stress cytokines, pain visual analogue scale (VAS) scores, knee mobility, and knee function hospital for special surgery (HSS) scores of the subjects were compared.
resultsAs the dose of TXA increased, the postoperative drainage volume, hidden bleeding, and total bleeding in TKA patients decreased, the levels of inflammatory factors interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) were reduced, the levels of stress factors malondialdehyde (MDA), angiotensin II (Ang II), and cortisol (Cor) were reduced, pain VAS scores decreased, and knee mobility increased, with an increase in functional HSS scores (P < 0.05).
conclusionThe administration of 20 mg/kg TXA in TKA patients visibly reduced bleeding following operation, improved the inflammation-stress response, and enhanced the function of the affected knee, which is beneficial to the postoperative recovery process.
Indexed as
Identifiers
39690362What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.