Evidence map›Paper›PMID 39690317›Full record

ArticlePsychopharmacology2025

Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior.

Joannes Luke B Asis, Ajina C Carampel, Jariel Naomi B Bacar, Johanna C Munar, Cynthia Grace C Gregorio, Paul Mark B Medina, Leslie Michelle M Dalmacio, Jesus Emmanuel A D Sevilleja, Gregory J Quirk, Rohani Cena-Navarro

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Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Joannes Luke B AsisCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Ajina C CarampelCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Jariel Naomi B BacarNational Institute of Molecular Biology and Biotechnology, National Institutes of Health, University of the Philippines Manila, 623 Pedro Gil Street, Ermita, 1000, Manila, Philippines.
Johanna C MunarNational Institute of Molecular Biology and Biotechnology, National Institutes of Health, University of the Philippines Manila, 623 Pedro Gil Street, Ermita, 1000, Manila, Philippines.
Cynthia Grace C GregorioInstitute of Chemistry, College of Science, University of the Philippines Diliman, Quezon City, Philippines.
Paul Mark B MedinaDepartment of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila, Philippines.
Leslie Michelle M DalmacioDepartment of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila, Philippines.
Jesus Emmanuel A D SevillejaMental Health Research Unit, Office for Special Concerns, National Center for Mental Health, Mandaluyong, Philippines.
Gregory J QuirkNational Institute of Molecular Biology and Biotechnology, National Institutes of Health, University of the Philippines Manila, 623 Pedro Gil Street, Ermita, 1000, Manila, Philippines.
Rohani Cena-NavarroNational Institute of Molecular Biology and Biotechnology, National Institutes of Health, University of the Philippines Manila, 623 Pedro Gil Street, Ermita, 1000, Manila, Philippines. rbcena@up.edu.ph.

Funding

Philippine Council for Health Research and Development DOST2020-04-A1-265
6 · The paper itself

Abstract

rationaleAdolescent inhalant use is an understudied and undertreated disorder, particularly in females. Chronic exposure to inhalants, like toluene, can have long-lasting effects on behavior. However, most animal studies lack the incorporation of both sexes and do not focus on the abstinence period.

objectiveWe assessed the behavioral effects during prolonged abstinence following repeated toluene inhalation in adolescent male and female rats.

methodsWe repeatedly exposed adolescent male and female Sprague Dawley rats to toluene vapor (1500 or 3000 ppm) for 6 days using the conditioned place preference (CPP) procedure. We tested drug-associated context preference, locomotion, anxiety-like behavior, object memory, social preference, and cognitive flexibility across 22 days of abstinence.

resultsIn females, 3000 ppm toluene increased CPP on days 8 and 22 of abstinence but this effect did not reach significance in males. Instead, males showed a significant increase in locomotion on days 7 and 21. Toluene also impaired social novelty preference and reversal learning during long-term abstinence, but not anxiety-like behavior or object recognition memory.

conclusionsOur rodent findings suggest that female inhalant users may show persistent drug preference during abstinence following chronic use. Furthermore, prolonged cognitive and social deficits should be addressed in treatment programs for adolescents.

Indexed as

Behavior, AnimalCognitionSocial BehaviorTolueneAdministration, InhalationAnimalsAnxietyFemaleLocomotionMaleRatsRats, Sprague-DawleySex FactorsTolueneAbstinenceAddictionConditioned place preferenceInhalantsReversalSocial novelty

Identifiers

PMID39690317
PMCPMC12084258

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.