Evidence map›Paper›PMID 39690277›Full record

ReviewMolecular biotechnology2025

Intertwining of Cellular Osmotic Stress Handling Mechanisms and Heavy Metal Accumulation.

Rosina Sánchez-Thomas, Mariel Hernández-Garnica, Juan Carlos Granados-Rivas, Emma Saavedra, Ignacio Peñalosa-Castro, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rosina Sánchez-ThomasDepartamento de Bioquímica, Instituto Nacional de Cardiología, 14080, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-3825-591X
Mariel Hernández-GarnicaDepartamento de Bioquímica, Instituto Nacional de Cardiología, 14080, Mexico City, Mexico.
Juan Carlos Granados-RivasCarrera de Biología, Laboratorio de Control Metabólico, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Reyes Ixtacala, Hab Los Reyes Ixtacala Barrio de los Árboles/Barrio de los Héroes, 54090, Tlalnepantla, Mexico.
Emma SaavedraDepartamento de Bioquímica, Instituto Nacional de Cardiología, 14080, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-8661-9813
Ignacio Peñalosa-CastroCarrera de Biología, Laboratorio de Control Metabólico, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Reyes Ixtacala, Hab Los Reyes Ixtacala Barrio de los Árboles/Barrio de los Héroes, 54090, Tlalnepantla, Mexico.ORCID http://orcid.org/0000-0002-5650-2398
Sara Rodríguez-EnríquezCarrera de Medico Cirujano, Laboratorio de Control Metabólico, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Reyes Ixtacala, Hab Los Reyes Ixtacala Barrio de los Árboles/Barrio de los Héroes, 54090, Tlalnepantla, Mexico. sara.rodriguez@iztacala.unam.mx.ORCID http://orcid.org/0000-0002-0822-1233
Rafael Moreno-SánchezCarrera de Biología, Laboratorio de Control Metabólico, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Reyes Ixtacala, Hab Los Reyes Ixtacala Barrio de los Árboles/Barrio de los Héroes, 54090, Tlalnepantla, Mexico. rafael.moreno@iztacala.unam.mx.ORCID http://orcid.org/0000-0002-9587-7184

Funding

DRUG POSITIVE INFANTS: REFERRING MOTHERS FOR TREATMENTR18DA006379 · NIDA · NATIONAL PUBLIC SERVICES RESEARCH INST · PI MARQUES, PAUL R · 1989 to 1993
–
Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCyT) de México 282663Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCyT) de México 6379PAPIIT, DGAPA-UNAM IA200l24PAPIIT, DGAPA-UNAM IA201823
6 · The paper itself

Abstract

Osmoregulation mechanisms are engaged in the detoxification and accumulation of heavy metals in plants, microalgae and other microorganisms. The present review paper analyzes osmotic resistance organisms and their heavy metal accumulation mechanisms closely related to osmoregulation. In prokaryotic and eukaryotic microorganisms, such as the green algae-like protist Euglena, osmotic and heavy metal stresses share similar cell responses and mechanisms. Likewise, some plants have developed specific mechanisms associated to water stress induced by salinity, flooding, or drought, which are also activated under heavy metal stress. Thus, synthesis of osmo-metabolites and strategies to maintain stable the intracellular water content under heavy metal exposure induce a state of apparent drought by blocking the water maintenance systems. Heavy metals affect the cellular redox state, triggering signaling pathways for intracellular water maintenance, which are mediated by the concentration of reactive oxygen species. Hence, cellular responses and mechanisms associated with osmotic stress, once fully elucidated, represent new opportunities to improve mechanistic strategies for bioremediation of heavy metal-polluted sites.

Indexed as

Metals, HeavyOsmoregulationOsmotic PressureMicroalgaePlantsStress, PhysiologicalMetals, HeavyHeavy metal accumulationHeavy metal bioremediationMicroorganismsOsmoregulation mechanismsOsmotic stress

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.