Evidence map›Paper›PMID 39690273›Full record

ArticleOncogene2025

Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer.

Jordan Alyse Woytash, Rahul Kumar, Ajay K Chaudhary, Cullan Donnelly, Adam Wojtulski, Murali Bethu, Jianmin Wang, Joseph Spernyak, Peter Bross, Neelu Yadav and 2 more

Abstract read
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Chaperonin in health and disease.Molecular biomedicine · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Turning down the heat in NEPC.Nature reviews. Urology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jordan Alyse WoytashDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.ORCID http://orcid.org/0000-0002-1276-947X
Rahul KumarDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Ajay K ChaudharyDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Cullan DonnellyDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Adam WojtulskiDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Murali BethuDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Jianmin WangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.ORCID http://orcid.org/0000-0001-7527-0409
Joseph SpernyakDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Peter BrossResearch Unit for Molecular Medicine, Aarhus University and Aarhus University Hospital, 8200, Aarhus N, Denmark.ORCID http://orcid.org/0000-0001-9526-8525
Neelu YadavDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Joseph R InigoDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Dhyan ChandraDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. dhyan.chandra@roswellpark.org.ORCID http://orcid.org/0000-0001-7272-9384

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
The Role of HSP60 in Alzheimer's DiseaseR01CA246437 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CHANDRA, DHYAN · 2021 to 2025
$2.2M
Hsp60 regulation of apoptosis in prostate cancerR01CA160685 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CHANDRA, DHYAN · 2013 to 2018
$1.1M
American Cancer Society (American Cancer Society, Inc.) MBG-21-048-01-MBGNCI NIH HHS P30 CA016056NCI NIH HHS R01 CA160685NCI NIH HHS R01 CA246437U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30CA016056U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA160685U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA246437
6 · The paper itself

Abstract

The mitochondrial unfolded protein response (UPR

Indexed as

beta CateninCarcinoma, NeuroendocrineMitochondriaProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantUnfolded Protein ResponseAnimalsCell Line, TumorChaperonin 60HumansMaleMiceMitochondrial ProteinsOxidative PhosphorylationSignal Transductionbeta CateninChaperonin 60HSPD1 protein, humanMitochondrial Proteins

Identifiers

PMID39690273
PMCPMC12314736

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.