Evidence map›Paper›PMID 39690251›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2025

The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients.

No-Ting Lin, Tsung-Yan Chen, Xue-Ming Wu, Yi-Yao Chang, Cheng-Hsuan Tsai, Che-Wei Liao, Tai-Shuan Lai, Chin-Chen Chang, Bo-Ching Lee, Ching-Chu Lu and 6 more

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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16 authors.

No-Ting LinDepartment of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan, ROC.
Tsung-Yan ChenDepartment of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan, ROC.
Xue-Ming WuDepartment of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan, ROC.
Yi-Yao ChangDepartment of Cardiovascular Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC.
Cheng-Hsuan TsaiDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Che-Wei LiaoDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Tai-Shuan LaiDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Chin-Chen ChangDepartment of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Bo-Ching LeeDepartment of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Ching-Chu LuDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Jeff Shih-Chieh ChuehDepartment of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Vin-Cent WuDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Chi-Sheng HungDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Zheng-Wei ChenDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC. librajohn7@hotmail.com.
Yen-Hung LinDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
TAIPAI Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KCNJ5 somatic mutations in aldosterone-producing adenoma (APA) are linked to higher left ventricular mass index (LVMI) and worse diastolic function. We previously identified an association between plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and an aldosterone-induced increase in LVMI and diastolic dysfunction. This study aimed to investigate the association between the presence of KCNJ5 somatic mutation and plasma TIMP-1 in APA patients. We enrolled 60 APA patients undergoing adrenalectomy, including 30 with KCNJ5 mutations (KCNJ5(+)) and 30 without (KCNJ5(-)). Clinical characteristics, echocardiographic data (including LVMI, inappropriately excessive LVMI (ieLVMI), and diastolic function) and plasma TIMP-1 levels were measured before surgery and 1 year postoperatively. The results showed that the KCNJ5(+) group had higher plasma TIMP-1 levels (P = 0.004) compared to the KCNJ5(-) group. The correlation between the KCNJ5 mutations and TIMP-1 levels remained significant after multiple regression analysis. To detect KCNJ5 mutations, receiver operating characteristic curve analysis showed TIMP-1 had the best area under the curve (AUC) value among various clinical parameters (AUC = 0.682, 95% confidence interval = 0.549-0.796, P = 0.008). Post-adrenalectomy, only the KCNJ5(+) group showed significant decrease in LVMI (P = 0.001) and log-transformed TIMP-1 levels (P = 0.035). Changes in ieLVMI before and after surgery were consistently correlated with changes in TIMP-1 levels in multivariable regression analysis. In conclusion, KCNJ5 somatic mutations in APA are associated with higher plasma TIMP-1 levels. In addition, TIMP-1 is an effective biomarker for detecting the presence of KCNJ5 mutations in APA patients.

Indexed as

AdenomaAdrenal Cortex NeoplasmsAldosteroneG Protein-Coupled Inwardly-Rectifying Potassium ChannelsMutationTissue Inhibitor of Metalloproteinase-1AdrenalectomyAdultAgedFemaleHumansMaleMiddle AgedAldosteroneG Protein-Coupled Inwardly-Rectifying Potassium ChannelsKCNJ5 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1Aldosterone-producing adenomaKCNJ5 somatic mutationMyocardial fibrosisPrimary aldosteronismTissue inhibitor of metalloproteinases-1

Identifiers

PMID39690251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.