Evidence map›Paper›PMID 39690178›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2025

Nebulized salbutamol for the treatment of transient tachypnea of the newborn: a randomized controlled trial.

Aditi Dhaka, Sonu Kumar, Poonam Singh, Mayank Priyadarshi, Suman Chaurasia, Nowneet Kumar Bhat, Sriparna Basu

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aditi DhakaDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Sonu KumarDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Poonam SinghDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Mayank PriyadarshiDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.ORCID http://orcid.org/0000-0002-4436-6181
Suman ChaurasiaDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.ORCID http://orcid.org/0000-0002-3871-5322
Nowneet Kumar BhatDepartment of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Sriparna BasuDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India. sriparna.neonat@aiimsrishikesh.edu.in.ORCID http://orcid.org/0000-0001-5048-4849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the efficacy of nebulized salbutamol in reducing respiratory distress in late preterm and term neonates with transient tachypnea of newborn (TTN). STUDY

designDouble-blind, placebo-controlled randomized trial.

methodsNeonates with TTN (n = 134) were allocated to nebulized salbutamol (n = 67) versus placebo (normal saline) (n = 67). The primary outcome was the duration of tachypnea (respiratory rate >60/min). Secondary outcomes were maximum Downes score and fraction of inspired oxygen (FiO

resultsMedian duration of tachypnea was 12.5 (10-16) vs. 12 (10.4-14) hours in salbutamol and placebo groups, respectively; p = 0.489. Almost all neonates received positive-pressure respiratory support at delivery room and subsequently. Maximum Downe's score, FiO

conclusionThere was no difference in the duration of tachypnea with nebulized salbutamol compared to placebo in late preterm and term neonates with TTN. CLINICAL

trial registrationClinical trial registry of India, Registration no: CTRI/2023/05/052441, Registered prospectively on 10/05/2023, https://ctri.icmr.org.in/.

Indexed as

Adrenergic beta-2 Receptor AgonistsAlbuterolBronchodilator AgentsTransient Tachypnea of the NewbornAdministration, InhalationDouble-Blind MethodFemaleHumansInfant, NewbornInfant, PrematureMaleNebulizers and VaporizersTreatment OutcomeAdrenergic beta-2 Receptor AgonistsAlbuterolBronchodilator Agents

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.