Evidence map›Paper›PMID 39689367›Full record

SynthesisThe American journal of tropical medicine and hygiene2025

Systematic Review and Meta-Analysis of Female Reproductive Health Following Ebola Virus Disease.

Madison Drogy, Celia Glezer, Emily Engel, Nell Bond, Keith Pickett, Jeffrey Shaffer, John Schieffelin, Crystal Zheng

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Madison DrogySchool of Public Health and Tropical Medicine, Tulane University Newcomb-Tulane College, New Orleans, Louisiana.
Celia GlezerSchool of Public Health and Tropical Medicine, Tulane University Newcomb-Tulane College, New Orleans, Louisiana.
Emily EngelDepartment of Pediatrics, Section of Pediatric Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana.
Nell BondDepartment of Immunology and Microbiology, School of Medicine, Tulane University, New Orleans, Louisiana.
Keith PickettRudolph Matas Library of the Health Sciences, Tulane University, New Orleans, Louisiana.
Jeffrey ShafferDepartment of Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.
John SchieffelinDepartment of Pediatrics, Section of Pediatric Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana.
Crystal ZhengDepartment of Medicine, Section of Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
West African Emerging Infectious Disease Research Center (WA-EIDRC)U01AI151812 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD, GARRY, ROBERT F · 2020 to 2024
$13.2M
Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus DiseaseR01AI123535 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISCHER, WILLIAM, WOHL, DAVID A · 2017 to 2021
$3.3M
NIAID NIH HHS R01 AI123535NIAID NIH HHS U01 AI151812NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

The viral hemorrhagic fevers Lassa fever (LF) and Ebola virus disease (EVD) have been documented to cause long-term health problems in survivors. Limited studies have noted the presence of adverse reproductive health outcomes, including menstrual irregularities and pregnancy loss, after recovery from infection. The objective of this systematic review and meta-analysis is to summarize existing knowledge surrounding reproductive health in female survivors of LF and EVD. Literature was gathered from PubMed, Embase, Ovid Medline, Cumulative Index of Nursing and Allied Health (CINAHL) Complete, Web of Science, and Global Health databases and subsequently reviewed in Covidence. Included studies described at least one reproductive health outcome in women after recovery from EVD or LF. Thirteen studies were identified in the systematic review, all of which only discussed reproductive health in EVD survivors. No studies of reproductive health among survivors of LF were identified. The included studies were conducted in Guinea, Sierra Leone, and Liberia, and they reported irregular menstruation, pregnancy loss, decreased libido, pelvic inflammatory disease, sexual dysfunction, female reproductive odor, and genital problems/infections among survivors. In a meta-analysis of nine studies, 14.0% of female EVD survivors experienced any adverse reproductive health outcome. However, there was significant heterogeneity among the included studies. This study highlights the health problems faced by female EVD survivors and underscores the need for more research surrounding the effects of viral hemorrhagic fevers on women's health.

Indexed as

Hemorrhagic Fever, EbolaReproductive HealthAbortion, SpontaneousEbolavirusFemaleHumansPregnancySurvivors

Identifiers

PMID39689367
PMCPMC11884292

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.