Evidence map›Paper›PMID 39689172›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers.

Maryam Kazerani, Filippo Cernilogar, Alessandra Pasquarella, Maria Hinterberger, Alexander Nuber, Ludger Klein, Gunnar Schotta

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Many Faces of SetDB1.Epigenomes · 2026
    Review
  5. Review
  6. Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maryam KazeraniDivision of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Martinsried 82152, Germany.ORCID 0000-0002-5803-4807
Filippo CernilogarDivision of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Martinsried 82152, Germany.ORCID 0000-0003-2814-3436
Alessandra PasquarellaDivision of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Martinsried 82152, Germany.
Maria HinterbergerInstitute for Immunology, Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Martinsried 82152, Germany.
Alexander NuberDivision of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Martinsried 82152, Germany.
Ludger KleinInstitute for Immunology, Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Martinsried 82152, Germany.
Gunnar SchottaDivision of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Martinsried 82152, Germany.ORCID 0000-0003-4940-6135

Funding

Deutsche Forschungsgemeinschaft (DFG) 210592381Deutsche Forschungsgemeinschaft (DFG) 213249687Deutsche Forschungsgemeinschaft (DFG) 456882036Deutsche Forschungsgemeinschaft (DFG) 490846870
6 · The paper itself

Abstract

The H3K9me3-specific histone methyltransferase SETDB1 is critical for proper regulation of developmental processes, but the underlying mechanisms are only partially understood. Here, we show that deletion of

Indexed as

Enhancer Elements, GeneticHematopoiesisHematopoietic Stem CellsHistone-Lysine N-MethyltransferaseAnimalsCell DifferentiationFetusHistonesLiverMiceHistone-Lysine N-MethyltransferaseHistonesSETDB1 protein, mouseepigeneticsERVH3K9me3hematopoietic stem cellsheterochromatin

Identifiers

PMID39689172
PMCPMC11670114

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.