Evidence map›Paper›PMID 39688881›Full record

ArticleIET systems biology

Transcriptomic analysis reveals pathways underlying the multi-antibiotic resistance of Klebsiella pneumoniae.

Ying Liu, Zhihui Niu, Rile Wu, Dezhi Yang, Jun Chen, Guoqing Liu, Jun Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IET systems biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying LiuInstitute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhihui NiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, China.
Rile WuDepartment of Thoracic Surgery, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Dezhi YangPharmaceutical Laboratory, Inner Mongolia International Mongolian Hospital, Hohhot, China.
Jun ChenInstitute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Guoqing LiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, China.ORCID 0000-0001-5190-4614
Jun ZhaoInstitute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

Corporate Partnership Program H230093Fundamental Research Funds for Inner Mongolia University of Science and TechnologyInnovation Support Program for Overseas Returnees of Inner Mongolia Autonomous RegionNational Natural Science Foundation of China 62161043Suzhou Municipal Basic Research Special Project SSD2024100
6 · The paper itself

Abstract

Klebsiella pneumoniae, an opportunistic pathogen, is pervasively distributed across the world. Its escalating antibiotic resistance poses a serious threat to global public health. The mechanisms behind this resistance remain largely elusive. In this study, we performed antibiotic susceptibility testing on several clinical isolates of Klebsiella pneumoniae, and a reference strain ATCC13883, and then analysed their transcriptomic profiles to identify genes and pathways associated with antibiotic resistance. Our results showed that a clinical isolate DY16KPN may counteract antibiotics by enhancing the biosynthesis of building blocks of bacterial cell, such as fatty acids, proteins, and DNA, and reducing transmembrane transport. Increased butanoate metabolism and lipopolysaccharide biosynthesis may also contribute to the drug-resistance of Klebsiella pneumoniae. Additionally, we identified resistance-promoting mutations in gene promoter regions, which regulate the activity of downstream drug-resistant genes and pathways. Our results also demonstrated that DY16KPN counterbalances the trimethoprim/sulfamethoxazole-mediated inhibitory effect on the synthesis of tetrahydrofolates and DNA by up-regulating the expression of targeted enzymes of trimethoprim/sulfamethoxazole, dihydrofolate reductase and dihydropteroate synthase.

Indexed as

Drug Resistance, Multiple, BacterialGene Expression ProfilingKlebsiella pneumoniaeTranscriptomeAnti-Bacterial AgentsGene Expression Regulation, BacterialMicrobial Sensitivity TestsAnti-Bacterial Agentsantibiotic resistancedifferentially expressed genesgene set enrichmenttransmembrane transport

Identifiers

PMID39688881
PMCPMC11831009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.