Evidence map›Paper›PMID 39688796›Full record

ReviewJournal of assisted reproduction and genetics2025

A review of the association between in vitro fertilization and children's neurocognitive development.

Nicholas Aderinto, Emmanuel Kokori, Gbolahan Olatunji, Ikponmwosa Jude Ogieuhi, Israel Charles Abraham, Bonaventure Michael Ukoaka, Adetola Emmanuel Babalola, Yewande Abigail Adebayo, Chimezirim Ezeano, Oluwaseun Oyewo and 1 more

Abstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicholas AderintoDepartment of Medicine and Surgery, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria.
Emmanuel KokoriDepartment of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria.
Gbolahan OlatunjiDepartment of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria.
Ikponmwosa Jude OgieuhiSiberian State Medical University, Tomsk, Russia. Jude.ogieuhi@gmail.com.ORCID http://orcid.org/0009-0003-9465-0089
Israel Charles AbrahamDepartment of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria.
Bonaventure Michael UkoakaDepartment of Internal Medicine, Asokoro District Hospital, Abuja, Nigeria.
Adetola Emmanuel BabalolaFaculty of Dentistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Yewande Abigail AdebayoGlangwili General Hospital, Carmarthen, Wales, UK.
Chimezirim EzeanoHealth Science Center, University of North Texas, Fort Worth, TX, USA.
Oluwaseun OyewoLennox Specialist Hospital, Lagos, Nigeria.
Ganiyat Adekemi AdeshinaDepartment of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, University of Lagos, Lagos, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review investigated the current research on the association between in vitro fertilization and children's neurocognitive development. Twenty studies were analyzed, encompassing over 23,000 children conceived through IVF, and compared to those conceived naturally. The findings on overall cognitive function were mixed, as measured by IQ. Some studies showed no significant differences between IVF and naturally conceived children, while others suggested slight variations. There is emerging evidence that IVF might correlate with specific cognitive domains like language and motor skills, although more research is needed. Several established factors, including maternal age, education level, and birth weight, are associated with children's cognitive development, regardless of conception method. Future research should explore how these factors interact with IVF and investigate a broader range of cognitive domains. Socioeconomic background and parental involvement are essential considerations for understanding a child's developmental trajectory. The inconclusive nature of some findings highlights the need for further research with larger sample sizes, more extended follow-up periods, and robust methodologies. This research has potential implications for parents considering IVF or ICSI, healthcare professionals providing guidance, and future efforts to tailor support systems for children conceived through assisted conception techniques. Open communication about the current state of knowledge and responsible communication of research findings is crucial.

Indexed as

Child DevelopmentCognitionFertilization in VitroChildFemaleHumansMalePregnancyCognitive functionIntracytoplasmic sperm injection (ICSI)In vitro fertilization (IVF)Neurocognitive development

Identifiers

PMID39688796
PMCPMC11950484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.