Evidence map›Paper›PMID 39688663›Full record

ArticleSkeletal radiology2025

Deep learning algorithm enables automated Cobb angle measurements with high accuracy.

Daichi Hayashi, Nor-Eddine Regnard, Jeanne Ventre, Vincent Marty, Lauryane Clovis, Ludovic Lim, Nicolas Nitche, Zekun Zhang, Antoine Tournier, Alexis Ducarouge and 3 more

Abstract read
In one paragraph

Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Large language models for lumbar spondylolisthesis detection: a multi-center pilot comparative radiographic accuracy study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
    Article
  4. Review
  5. Article
  6. AI model for automatic spinopelvic and spinal alignment parameters measurement from EOS.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daichi HayashiDepartment of Radiology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA. daichi.alex.hayashi@gmail.com.ORCID http://orcid.org/0000-0002-2067-5780
Nor-Eddine RegnardRéseau Imagerie Sud Francilien, Lieusaint, France.
Jeanne VentreGleamer, Paris, France.
Vincent MartyGleamer, Paris, France.
Lauryane ClovisGleamer, Paris, France.
Ludovic LimGleamer, Paris, France.
Nicolas NitcheGleamer, Paris, France.
Zekun ZhangGleamer, Paris, France.
Antoine TournierGleamer, Paris, France.
Alexis DucarougeGleamer, Paris, France.
Andrew J KompelDepartment of Radiology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.
Chadi TannouryDepartment of Orthopedic Surgery, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.
Ali GuermaziDepartment of Radiology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the accuracy of automatic Cobb angle measurements by deep learning (DL) on full spine radiographs. MATERIALS AND

methodsFull spine radiographs of patients aged > 2 years were screened using the radiology reports to identify radiographs for performing Cobb angle measurements. Two senior musculoskeletal radiologists and one senior orthopedic surgeon independently annotated Cobb angles exceeding 7° indicating the angle location as either proximal thoracic (apices between T3 and T5), main thoracic (apices between T6 and T11), or thoraco-lumbar (apices between T12 and L4). If at least two readers agreed on the number of angles, location of the angles, and difference between comparable angles was < 8°, then the ground truth was defined as the mean of their measurements. Otherwise, the radiographs were reviewed by the three annotators in consensus. The DL software (BoneMetrics, Gleamer) was evaluated against the manual annotation in terms of mean absolute error (MAE).

resultsA total of 345 patients were included in the study (age 33 ± 24 years, 221 women): 179 pediatric patients (< 22 years old) and 166 adult patients (22 to 85 years old). Fifty-three cases were reviewed in consensus. The MAE of the DL algorithm for the main curvature was 2.6° (95% CI [2.0; 3.3]). For the subgroup of pediatric patients, the MAE was 1.9° (95% CI [1.6; 2.2]) versus 3.3° (95% CI [2.2; 4.8]) for adults.

conclusionThe DL algorithm predicted the Cobb angle of scoliotic patients with high accuracy.

Indexed as

Deep LearningRadiographic Image Interpretation, Computer-AssistedScoliosisAdolescentAdultAgedAged, 80 and overAlgorithmsChildChild, PreschoolFemaleHumansMaleMiddle AgedReproducibility of ResultsRetrospective StudiesCobb angleDeep learningRadiographScoliosis

Identifiers

PMID39688663
PMCPMC12078391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.