Evidence map›Paper›PMID 39688405›Full record

ArticlemSphere2025

Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting

Lao-Tzu Allan-Blitz, Gordon Adams, Gabriela Sanders, Palak Shah, Krithik Ramesh, Jana Jarolimova, Kevin L Ard, John A Branda, Jeffrey D Klausner, Pardis C Sabeti and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Rapid Cas13a-basedmSphere · 2026
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Lao-Tzu Allan-BlitzDivision of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-4077-3476
Gordon AdamsBroad Institute of Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, USA.
Gabriela SandersBroad Institute of Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, USA.
Palak ShahBroad Institute of Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, USA.
Krithik RameshMassachusetts Institute of Technology, Boston, Massachusetts, USA.
Jana JarolimovaDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kevin L ArdDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
John A BrandaDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jeffrey D KlausnerDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-6922-7364
Pardis C SabetiBroad Institute of Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, USA.
Jacob E LemieuxBroad Institute of Massachusetts Institute of Technology and Harvard, Boston, Massachusetts, USA.ORCID 0000-0002-2758-4005

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI SABETI, PARDIS CHRISTINE · 2014 to 2024
$66.5M
The development & pilot implementation of a CRISPR-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settingsK23AI182453 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Lao-Tzu Allan-Blitz · 2024 to 2026
$585k
NIAID NIH HHS K23 AI182453NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

Nucleic acid amplification testing (NAAT) for

Indexed as

CRISPR-Cas SystemsGonorrheaMolecular Diagnostic TechniquesNeisseria gonorrhoeaeNucleic Acid Amplification TechniquesDNA, BacterialHumansMachine LearningMaleSensitivity and SpecificitySmartphoneDNA, BacterialCas13aclinical specimensCRISPRlateral flowNeisseria gonorrhoeaepoint of care diagnostic

Identifiers

PMID39688405
PMCPMC11774021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.