Evidence map›Paper›PMID 39688371›Full record

ArticleeLife2024

Control of 3' splice site selection by the yeast splicing factor Fyv6.

Katherine A Senn, Karli A Lipinski, Natalie J Zeps, Amory F Griffin, Max E Wilkinson, Aaron A Hoskins

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Control of 3' splice site selection inRNA (New York, N.Y.) · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Katherine A Senn *Department of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0003-2172-7113
Karli A Lipinski *Department of Chemistry, University of Wisconsin-Madison, Madison, United States.
Natalie J ZepsDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.
Amory F GriffinDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.
Max E WilkinsonMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Aaron A HoskinsDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0002-9777-519X

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Mechanisms of Spliceosome Assembly and RegulationR35GM136261 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Aaron Andrew Hoskins · 2020 to 2026
$3.2M
National Science Foundation Graduate Research Fellowship Program DGE-1747503NIGMS NIH HHS R35 GM136261NIGMS NIH HHS T32 GM008349NIGMS NIH HHS T32 GM135066NIH HHS R35 GM136261NIH HHS T32 GM135066
6 · The paper itself

Abstract

Pre-mRNA splicing is catalyzed in two steps: 5' splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (first and second step factors). We recently identified Fyv6 (FAM192A in humans) as a second step factor in

Indexed as

Cryoelectron MicroscopyRNA Splice SitesRNA SplicingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDEAD-box RNA HelicasesProtein BindingRNA Splicing FactorsSpliceosomesDEAD-box RNA HelicasesPRP22 protein, S cerevisiaeRNA Splice SitesRNA Splicing FactorsSaccharomyces cerevisiae Proteinsbiochemistrychemical biologycryo-EMmolecular biophysicspre-mRNARNA-seqS. cerevisiaespliceosomesplicingstructural biologyyeast

Identifiers

PMID39688371
PMCPMC11651659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.