Evidence map›Paper›PMID 39688350›Full record

ArticlePediatric pulmonology2025

Implementation of the Oxygen Saturation Index as a Predictor of Outcome in Prenatally Diagnosed CDH Neonates in the First 24 Hours of Life.

Lennart Hale, Judith Leyens, Bartolomeo Bo, Clara Engel, Christoph Berg, Lukas Schroeder, Andreas Mueller, Florian Kipfmueller

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Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lennart HaleDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.
Judith LeyensDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.
Bartolomeo BoDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-5187-1346
Clara EngelDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.
Christoph BergDepartment of Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, Germany.
Lukas SchroederDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-6501-2243
Andreas MuellerDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.
Florian KipfmuellerDepartment of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-7414-757X

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

aimsThis study aimed to evaluate the Oxygen Saturation Index (OSI) as a noninvasive measure for early postnatal management and outcome prediction in neonates with congenital diaphragmatic hernia (CDH). Additionally, the study analyzed the correlation and predictive ability of OSI, Oxygenation Index (OI), Horovitz Index (HI), and partial pressure of arterial oxygen (PaO

methodsA retrospective, single-center study using data from 2013 to 2020. Parameters for calculating indices were extracted from patient charts every hour during the first 24 h of life. Statistical analyses included ROC analysis for predictive cut-off values and Spearman's rank for correlation assessments.

resultsThe study included 138 neonates. Postductal OSI demonstrated high sensitivity (80%-85%) and negative predictive value (NPV) for predicting mortality and ECMO need, with cut-off values between 11.5 and 13. Optimal cut-off values for predicting ECMO need were 10 at 12 and 24 h (sensitivity 96.7%). OSI, OI, HI, and PaO

conclusionOSI is a promising index for predicting outcomes in CDH neonates, showing strong correlation with indices like OI and HI. Despite limitations, OSI provides continuous, bedside monitoring without invasive blood sampling. Further prospective studies are needed to validate these findings and establish new cut-off values.

Indexed as

Hernias, Diaphragmatic, CongenitalOxygenOxygen SaturationExtracorporeal Membrane OxygenationFemaleHumansInfant, NewbornMalePredictive Value of TestsPrenatal DiagnosisRetrospective StudiesSensitivity and SpecificityOxygencongenital diaphragmatic herniaextracorporeal membrane oxygenationoutcome predictionOxygenation IndexOxygen Saturation Index

Identifiers

PMID39688350
PMCPMC11748113

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.