Evidence map›Paper›PMID 39688305›Full record

Observational studyClinical obesity2025

Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low-calorie diet.

Adam C Lowe, Dorien Reijnders, Charmaine S Tam, Leanne M Redman, Robbie Beyl, Karl A LeBlanc, Mark G Hausmann, Vance L Albaugh, Frank L Greenway, Eric Ravussin

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam C LoweHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-6907-1056
Dorien ReijndersHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-6637-4553
Charmaine S TamHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-4034-9923
Leanne M RedmanHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-7267-7374
Robbie BeylHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-8582-744X
Karl A LeBlancOur Lady of the Lake Physician Group, Franciscan Missionaries of Our Lady Health System, Baton Rouge, Louisiana, USA.
Mark G HausmannOur Lady of the Lake Physician Group, Franciscan Missionaries of Our Lady Health System, Baton Rouge, Louisiana, USA.
Vance L AlbaughHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-5267-8951
Frank L GreenwayHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-1766-6111
Eric RavussinHuman Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0003-2129-547X

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
National Institute of Diabetes & Digestive & Kidney Diseases P30DK072476NIDDK NIH HHS P30 DK072476
6 · The paper itself

Abstract

The endocrine consequences of weight loss by bariatric surgery (BS) and caloric restriction are not fully understood but contribute to variable improvements in insulin sensitivity and cardiometabolic health. This study compared changes in insulin sensitivity and plasma concentrations of gut peptides 8 weeks and 1 year after BS and a low-calorie diet (LCD). Nineteen female patients with obesity self-selected BS (gastric bypass [n = 5] or sleeve gastrectomy [n = 7]) or LCD (n = 7) in this parallel-arm, prospective observational study. We assessed insulin sensitivity via a two-step hyperinsulinemic-euglycemic clamp (20 and 80 mU/min/m

Indexed as

Bariatric SurgeryCaloric RestrictionInsulin ResistanceObesity, MorbidAdultBlood GlucoseFemaleGhrelinHumansInsulinMiddle AgedPeptide YYProspective StudiesWeight LossBlood GlucoseGhrelinInsulinPeptide YYappetitebariatric surgeryeuglycemic clampgastric bypassPYYweight loss

Identifiers

PMID39688305
PMCPMC12199209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.